2-(2-chlorophenyl)-2-oxoethyl thiocyanate

Base Information

• Chemical Name: 2-(2-chlorophenyl)-2-oxoethyl thiocyanate
• CAS No.: 19339-58-3
• Molecular Formula: C9H6 Cl N O S
• Molecular Weight: 211.672
• Hs Code.: 2930909090
• Mol file: 19339-58-3.mol

Synonyms:Thiocyanicacid, o-chlorophenacyl ester (8CI)

Chemical Property of 2-(2-chlorophenyl)-2-oxoethyl thiocyanate

Chemical Property:

• Vapor Pressure: 0.000107mmHg at 25°C
• Melting Point: 56-58°
• Refractive Index: 1.601
• Boiling Point: 337.2°Cat760mmHg
• Flash Point: 157.7°C
• PSA: 66.16000
• Density: 1.35g/cm³
• LogP: 2.73698

Purity/Quality:

98%Min ^*data from raw suppliers

2-(2-Chlorophenyl)-2-oxoethylThiocyanate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(2-chlorophenyl)-2-oxoethyl thiocyanate

There total 5 articles about 2-(2-chlorophenyl)-2-oxoethyl thiocyanate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

1-(2-chlorophenyl)ethanone (2142-68-9) + ammonium thiocyanate (1147550-11-5) → 2-thiocyanato-1-(2-chlorophenyl)ethanone (19339-58-3)

Guidance literature:

With pyridinium hydrobromide perbromide; In acetonitrile; at 0 - 20 ℃; for 1.5h; regioselective reaction;

DOI:10.1080/10426507.2011.616561

Reference yield: 68.0%

ammonium thiocyanate + 2-chlorostyrene (2039-87-4,107830-52-4,26125-41-7) → 2-thiocyanato-1-(2-chlorophenyl)ethanone (19339-58-3)

Guidance literature:

With oxygen; In acetic acid; at 25 ℃; for 8h;

DOI:10.1016/j.tet.2015.04.071

Reference yield: 55.0%

2-chlorostyrene (2039-87-4,107830-52-4,26125-41-7) + ammonium thiocyanate (1147550-11-5) → 2-thiocyanato-1-(2-chlorophenyl)ethanone (19339-58-3)

Guidance literature:

With oxygen; In ethanol; at 25 ℃;

upstream raw materials:

1-(2-chlorophenyl)ethanone

ammonium thiocyanate

2-chlorostyrene

sodium thiocyanide

Refernces

• 1、 -. "A 2-thiocyano HYPNONE derivatives method for the preparation of". Paragraph 0068-0071. . Retrieved 2016/10/10.
• 2、 Wu, Liqiang,Yang, Xiaojuan. "Efficient α-thiocyanation of ketones using pyridinium hydrobromide perbromide". experimental part. p. 748 - 753. Retrieved 2012/06/18.