(S)-4-[4-(4-benzoylamino-phenylamino)-3-cyano-6-methoxy-quinolin-7-yloxy]-2-tert-butoxycarbonylamino-butyric acid cyclopentyl ester

Base Information

• Chemical Name: (S)-4-[4-(4-benzoylamino-phenylamino)-3-cyano-6-methoxy-quinolin-7-yloxy]-2-tert-butoxycarbonylamino-butyric acid cyclopentyl ester
• CAS No.: 914488-12-3
• Molecular Formula: C₃₈H₄₁N₅O₇
• Molecular Weight: 679.773
• Mol file: 914488-12-3.mol

Synonyms:(S)-4-[4-(4-benzoylamino-phenylamino)-3-cyano-6-methoxy-quinolin-7-yloxy]-2-tert-butoxycarbonylamino-butyric acid cyclopentyl ester

Chemical Property of (S)-4-[4-(4-benzoylamino-phenylamino)-3-cyano-6-methoxy-quinolin-7-yloxy]-2-tert-butoxycarbonylamino-butyric acid cyclopentyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-4-[4-(4-benzoylamino-phenylamino)-3-cyano-6-methoxy-quinolin-7-yloxy]-2-tert-butoxycarbonylamino-butyric acid cyclopentyl ester

There total 14 articles about (S)-4-[4-(4-benzoylamino-phenylamino)-3-cyano-6-methoxy-quinolin-7-yloxy]-2-tert-butoxycarbonylamino-butyric acid cyclopentyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-2-tert-butoxycarbonylamino-4-hydroxy-butyric acid cyclopentyl ester (914382-64-2) + N-[4-(3-cyano-7-hydroxy-6-methoxy-quinolin-4-ylamino)-phenyl]-benzamide (914490-16-7) → (S)-4-[4-(4-benzoylamino-phenylamino)-3-cyano-6-methoxy-quinolin-7-yloxy]-2-tert-butoxycarbonylamino-butyric acid cyclopentyl ester (914488-12-3)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In dichloromethane; at 0 - 20 ℃; for 18.5h;

Reference yield:

7-benzyloxy-4-chloro-6-methoxyquinoline-3-carbonitrile (214476-99-0) → (S)-4-[4-(4-benzoylamino-phenylamino)-3-cyano-6-methoxy-quinolin-7-yloxy]-2-tert-butoxycarbonylamino-butyric acid cyclopentyl ester (914488-12-3)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / ethanol / 4 h / Heating / reflux

2: ethanol; cyclohexene / palladium 10% on activated carbon / 18 h / Heating / reflux

3: di-isopropyl azodicarboxylate; triphenylphosphine / dichloromethane / 18.5 h / 0 - 20 °C

With pyridine; ethanol; di-isopropyl azodicarboxylate; triphenylphosphine; cyclohexene; palladium 10% on activated carbon; In ethanol; dichloromethane;

Reference yield:

7-benzyloxy-6-methoxy-4-oxo-1,4-dihydro-quinoline-3-carbonitrile (214476-89-8,914490-11-2) → (S)-4-[4-(4-benzoylamino-phenylamino)-3-cyano-6-methoxy-quinolin-7-yloxy]-2-tert-butoxycarbonylamino-butyric acid cyclopentyl ester (914488-12-3)

Guidance literature:

Multi-step reaction with 4 steps

1: trichlorophosphate / 2 h / Heating / reflux

2: pyridine / ethanol / 4 h / Heating / reflux

3: ethanol; cyclohexene / palladium 10% on activated carbon / 18 h / Heating / reflux

4: di-isopropyl azodicarboxylate; triphenylphosphine / dichloromethane / 18.5 h / 0 - 20 °C

With pyridine; ethanol; di-isopropyl azodicarboxylate; triphenylphosphine; cyclohexene; trichlorophosphate; palladium 10% on activated carbon; In ethanol; dichloromethane;

upstream raw materials:

(S)-2-tert-butoxycarbonylamino-4-hydroxy-butyric acid cyclopentyl ester

N-[4-(3-cyano-7-hydroxy-6-methoxy-quinolin-4-ylamino)-phenyl]-benzamide

7-benzyloxy-4-chloro-6-methoxyquinoline-3-carbonitrile

(S)-2-tert-butoxycarbonylamino-4-(tert-butyl-dimethyl-silanyloxy)-butyric acid cyclopentyl ester