N-(4-(4-acetamido-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)-4-chloro-3-(trifluoromethyl)benzamide

Base Information

Chemical Name:N-(4-(4-acetamido-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)-4-chloro-3-(trifluoromethyl)benzamide
CAS No.:1173701-45-5
Molecular Formula:C₂₂H₁₅ClF₃N₅O₂
Molecular Weight:473.842
Hs Code.:

Synonyms:N-(4-(4-acetamido-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)-4-chloro-3-(trifluoromethyl)benzamide

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Chemical Property of N-(4-(4-acetamido-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)-4-chloro-3-(trifluoromethyl)benzamide

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Technology Process of N-(4-(4-acetamido-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)-4-chloro-3-(trifluoromethyl)benzamide

There total 7 articles about N-(4-(4-acetamido-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)-4-chloro-3-(trifluoromethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 1173701-33-1
N-(7-(4-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)acetamide

: 1737-36-6
4-chloro-3-(trifluoromethyl)benzoic acid

: 1173701-45-5
N-(4-(4-acetamido-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)-4-chloro-3-(trifluoromethyl)benzamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 80 ℃;
DOI:10.1016/j.bmcl.2009.10.051

Reference yield:

: 74895-37-7
2-Cyan-4,4-diethoxybuttersaeurenitril

: 1173701-45-5
N-(4-(4-acetamido-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)-4-chloro-3-(trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 7 steps

1: potassium tert-butylate / ethanol / 0 °C / Reflux

2: hydrogenchloride / water / 1.17 h / 50 °C

3: Raney-Nickel / water / 4 h / Reflux

4: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 24 h / 0 - 80 °C / Inert atmosphere

5: potassium carbonate; copper(l) iodide; L-proline / dimethyl sulfoxide / 40 h / 90 °C / Inert atmosphere

6: palladium on activated charcoal; hydrogen / tetrahydrofuran / 2 h / 2585.81 Torr

7: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 24 h / 0 - 80 °C / Inert atmosphere

With hydrogenchloride; copper(l) iodide; palladium on activated charcoal; potassium tert-butylate; hydrogen; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; L-proline; In tetrahydrofuran; ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1248/cpb.c13-00249

Reference yield:

: 370584-51-3
N-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)acetamide

: 1173701-45-5
N-(4-(4-acetamido-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)-4-chloro-3-(trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate; copper(l) iodide; L-proline / dimethyl sulfoxide / 40 h / 90 °C / Inert atmosphere

2: palladium on activated charcoal; hydrogen / tetrahydrofuran / 2 h / 2585.81 Torr

3: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 24 h / 0 - 80 °C / Inert atmosphere

With copper(l) iodide; palladium on activated charcoal; hydrogen; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; L-proline; In tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1248/cpb.c13-00249