(+)-(S)-α-phenyl-α-trifluoromethylglycine methyl ester

Base Information

Chemical Name:(+)-(S)-α-phenyl-α-trifluoromethylglycine methyl ester
CAS No.:1241680-72-7
Molecular Formula:C₁₀H₁₀F₃NO₂
Molecular Weight:233.19
Hs Code.:

Synonyms:(+)-(S)-α-phenyl-α-trifluoromethylglycine methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+)-(S)-α-phenyl-α-trifluoromethylglycine methyl ester

Chemical Property:

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Technology Process of (+)-(S)-α-phenyl-α-trifluoromethylglycine methyl ester

There total 3 articles about (+)-(S)-α-phenyl-α-trifluoromethylglycine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (+)-(S)-α-phenyl-α-trifluoromethylglycine

: 18107-18-1
diazomethyl-trimethyl-silane

: 1241680-72-7
(+)-(S)-α-phenyl-α-trifluoromethylglycine methyl ester

Guidance literature:: With methanol; In diethyl ether; toluene; at 20 ℃; for 0.5h;
DOI:10.1016/j.tetasy.2010.11.029

Reference yield:

: 434-45-7
2,2,2-Trifluoroacetophenone

: 1241680-72-7
(+)-(S)-α-phenyl-α-trifluoromethylglycine methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: ethanol; water / 38 h / 110 - 120 °C / Autoclave

2.1: ethanol / 48 h / -15 - 30 °C / Resolution of racemate; Auto-seeded programmed polythermic preferential crystallization

3.1: barium hydroxide octahydrate / water / 72 h / Reflux

3.2: 20 °C / pH 1

3.3: DOWEX 50WX₈-100 (H⁺ form)

4.1: methanol / diethyl ether; toluene / 0.5 h / 20 °C

With methanol; barium hydroxide octahydrate; In diethyl ether; ethanol; water; toluene; 1.1: Bucherer-Bergs reaction;
DOI:10.1016/j.tetasy.2010.11.029

Reference yield:

: 1280716-66-6
(+)-(S)-5-phenyl-5-(trifluoromethyl)hydantoin

: 1241680-72-7
(+)-(S)-α-phenyl-α-trifluoromethylglycine methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: barium hydroxide octahydrate / water / 72 h / Reflux

1.2: 20 °C / pH 1

1.3: DOWEX 50WX₈-100 (H⁺ form)

2.1: methanol / diethyl ether; toluene / 0.5 h / 20 °C

With methanol; barium hydroxide octahydrate; In diethyl ether; water; toluene;
DOI:10.1016/j.tetasy.2010.11.029