5-benzyloxy-6-hydroxy-2-(1-naphthalen-1-ylcyclopentylmethyl)pyrimidine-4-carboxylic acid (2-hydroxyethyl)methylamide

Base Information

Chemical Name:5-benzyloxy-6-hydroxy-2-(1-naphthalen-1-ylcyclopentylmethyl)pyrimidine-4-carboxylic acid (2-hydroxyethyl)methylamide
CAS No.:1616924-99-2
Molecular Formula:C₃₁H₃₃N₃O₄
Molecular Weight:511.621
Hs Code.:

Synonyms:5-benzyloxy-6-hydroxy-2-(1-naphthalen-1-ylcyclopentylmethyl)pyrimidine-4-carboxylic acid (2-hydroxyethyl)methylamide

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Chemical Property of 5-benzyloxy-6-hydroxy-2-(1-naphthalen-1-ylcyclopentylmethyl)pyrimidine-4-carboxylic acid (2-hydroxyethyl)methylamide

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Technology Process of 5-benzyloxy-6-hydroxy-2-(1-naphthalen-1-ylcyclopentylmethyl)pyrimidine-4-carboxylic acid (2-hydroxyethyl)methylamide

There total 13 articles about 5-benzyloxy-6-hydroxy-2-(1-naphthalen-1-ylcyclopentylmethyl)pyrimidine-4-carboxylic acid (2-hydroxyethyl)methylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1616924-98-1
5-benzyloxy-6-hydroxy-2-(1-naphthalen-1-ylcyclopentylmethyl)pyrimidine-4-carboxylic acid [2-(tert-butyldimethylsilanyloxy)ethyl]methylamide

: 1616924-99-2
5-benzyloxy-6-hydroxy-2-(1-naphthalen-1-ylcyclopentylmethyl)pyrimidine-4-carboxylic acid (2-hydroxyethyl)methylamide

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; water; at 20 ℃; for 1h;

Reference yield:

: 1616924-93-6
5-benzyloxy-6-hydroxy-2-(1-naphthalen-1-ylcyclopentylmethyl)pyrimidine-4-carboxylic acid tert-butyl ester

: 1616924-99-2
5-benzyloxy-6-hydroxy-2-(1-naphthalen-1-ylcyclopentylmethyl)pyrimidine-4-carboxylic acid (2-hydroxyethyl)methylamide

Guidance literature:: Multi-step reaction with 3 steps

1: lithium hydroxide monohydrate / tetrahydrofuran; water / 20 h / Reflux

2: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1.5 h / 20 °C

3: hydrogenchloride / tetrahydrofuran; water / 1 h / 20 °C

With hydrogenchloride; lithium hydroxide monohydrate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; water; N,N-dimethyl-formamide;

Reference yield:

: 1616924-94-7
5-benzyloxy-6-hydroxy-2-(1-naphthalen-1-ylcyclopentylmethyl)pyrimidine-4-carboxylic acid

: 1616924-99-2
5-benzyloxy-6-hydroxy-2-(1-naphthalen-1-ylcyclopentylmethyl)pyrimidine-4-carboxylic acid (2-hydroxyethyl)methylamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1.5 h / 20 °C

2: hydrogenchloride / tetrahydrofuran; water / 1 h / 20 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; water; N,N-dimethyl-formamide;