methyl 4-{2-[5-chloro-2-(2-{[(2-chlorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylmethyl)-1H-indol-3-yl]ethoxy}benzoate

Base Information

• Chemical Name: methyl 4-{2-[5-chloro-2-(2-{[(2-chlorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylmethyl)-1H-indol-3-yl]ethoxy}benzoate
• CAS No.: 934286-16-5
• Molecular Formula: C₄₀H₃₆Cl₂N₂O₅S
• Molecular Weight: 727.708
• Mol file: 934286-16-5.mol

Synonyms:methyl 4-{2-[5-chloro-2-(2-{[(2-chlorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylmethyl)-1H-indol-3-yl]ethoxy}benzoate

Chemical Property of methyl 4-{2-[5-chloro-2-(2-{[(2-chlorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylmethyl)-1H-indol-3-yl]ethoxy}benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 4-{2-[5-chloro-2-(2-{[(2-chlorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylmethyl)-1H-indol-3-yl]ethoxy}benzoate

There total 6 articles about methyl 4-{2-[5-chloro-2-(2-{[(2-chlorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylmethyl)-1H-indol-3-yl]ethoxy}benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

methyl 4-{2-[2-(2-aminoethyl)-1-benzhydryl-5-chloro-1H-indol-3-yl]ethoxy}benzoate amine (540522-69-8) + (2-chlorobenzyl)sulfonyl chloride (77421-13-7) → methyl 4-{2-[5-chloro-2-(2-{[(2-chlorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylmethyl)-1H-indol-3-yl]ethoxy}benzoate (934286-16-5)

Guidance literature:

With sodium hydrogencarbonate; In dichloromethane;

DOI:10.1021/jm061131z

Reference yield: 86.0%

→ methyl 4-{2-[5-chloro-2-(2-{[(2-chlorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylmethyl)-1H-indol-3-yl]ethoxy}benzoate (934286-16-5)

Guidance literature:

Reference yield:

methyl 4-[2-[5-chloro-(1-diphenylmethyl)-2-methyl-1H-indol-3-yl]ethoxy]benzoate (479422-24-7) → methyl 4-{2-[5-chloro-2-(2-{[(2-chlorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylmethyl)-1H-indol-3-yl]ethoxy}benzoate (934286-16-5)

Guidance literature:

Multi-step reaction with 5 steps

1: NBS; benzoyl peroxide / CCl₄ / 2.5 h / Heating

2: 0.750 g / Ag₂CO₃; H₂O / acetone

3: 23 percent / NH₄OAc / 4 h / Heating

4: 65 percent / Zn(Hg); aq. HCl / tetrahydrofuran / 1 h

5: 86 percent / aq. NaHCO₃ / CH₂Cl₂

With hydrogenchloride; N-Bromosuccinimide; ammonium acetate; water; sodium hydrogencarbonate; silver carbonate; mercury; zinc; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; dichloromethane; acetone; 3: Henry reaction / 5: Schotten-Baumann reaction;

DOI:10.1021/jm061131z

upstream raw materials:

methyl 4-{2-[2-(2-aminoethyl)-1-benzhydryl-5-chloro-1H-indol-3-yl]ethoxy}benzoate amine

(2-chlorobenzyl)sulfonyl chloride

methyl 4-[2-[5-chloro-(1-diphenylmethyl)-2-methyl-1H-indol-3-yl]ethoxy]benzoate

methyl 4-(2-{5-chloro-1-(diphenylmethyl)-2-[(E)-2-nitrovinyl]-1H-indol-3-yl}ethoxy)benzoate