Technology Process of 2-allyl-1-azido-3,5-dimethylbenzene
There total 5 articles about 2-allyl-1-azido-3,5-dimethylbenzene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tert.-butylnitrite; trimethylsilylazide;
In
acetonitrile;
at 0 - 20 ℃;
DOI:10.1021/ol301120w
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere
1.2: 0 °C / Inert atmosphere; Reflux
2.1: acetyl chloride / methanol / 2 h / 0 - 20 °C / Inert atmosphere
3.1: boron trifluoride diethyl etherate / 5,5-dimethyl-1,3-cyclohexadiene / 16 h / Inert atmosphere; Reflux
4.1: tert.-butylnitrite; trimethylsilylazide / acetonitrile / 0 - 20 °C
With
tert.-butylnitrite; trimethylsilylazide; boron trifluoride diethyl etherate; sodium hydride; acetyl chloride;
In
tetrahydrofuran; methanol; 5,5-dimethyl-1,3-cyclohexadiene; acetonitrile;
3.1: Claisen rearrangement;
DOI:10.1021/ol301120w
- Guidance literature:
-
Multi-step reaction with 3 steps
1: acetyl chloride / methanol / 2 h / 0 - 20 °C / Inert atmosphere
2: boron trifluoride diethyl etherate / 5,5-dimethyl-1,3-cyclohexadiene / 16 h / Inert atmosphere; Reflux
3: tert.-butylnitrite; trimethylsilylazide / acetonitrile / 0 - 20 °C
With
tert.-butylnitrite; trimethylsilylazide; boron trifluoride diethyl etherate; acetyl chloride;
In
methanol; 5,5-dimethyl-1,3-cyclohexadiene; acetonitrile;
2: Claisen rearrangement;
DOI:10.1021/ol301120w
