12-(benzyloxy)-12-oxo-1-dodecyl (2S)-1-(4-((benzyloxy)methoxy)-3,3-dimethyl-1,2-dioxobutyl)-2-piperidinecarboxylate

Base Information

Chemical Name:12-(benzyloxy)-12-oxo-1-dodecyl (2S)-1-(4-((benzyloxy)methoxy)-3,3-dimethyl-1,2-dioxobutyl)-2-piperidinecarboxylate
CAS No.:152754-51-3
Molecular Formula:C₃₉H₅₅NO₈
Molecular Weight:665.868
Hs Code.:

Synonyms:12-(benzyloxy)-12-oxo-1-dodecyl (2S)-1-(4-((benzyloxy)methoxy)-3,3-dimethyl-1,2-dioxobutyl)-2-piperidinecarboxylate

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Chemical Property of 12-(benzyloxy)-12-oxo-1-dodecyl (2S)-1-(4-((benzyloxy)methoxy)-3,3-dimethyl-1,2-dioxobutyl)-2-piperidinecarboxylate

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Technology Process of 12-(benzyloxy)-12-oxo-1-dodecyl (2S)-1-(4-((benzyloxy)methoxy)-3,3-dimethyl-1,2-dioxobutyl)-2-piperidinecarboxylate

There total 7 articles about 12-(benzyloxy)-12-oxo-1-dodecyl (2S)-1-(4-((benzyloxy)methoxy)-3,3-dimethyl-1,2-dioxobutyl)-2-piperidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 99837-97-5
benzyl 12-hydroxydodecanoate

: 152754-49-9
(2S)-1-(4-((benzyloxy)methoxy)-3,3-dimethyl-1,2-dioxobutyl)-2-piperidinecarboxylic acid

: 152754-51-3
12-(benzyloxy)-12-oxo-1-dodecyl (2S)-1-(4-((benzyloxy)methoxy)-3,3-dimethyl-1,2-dioxobutyl)-2-piperidinecarboxylate

Guidance literature:: With dmap; (1S)-10-camphorsulfonic acid; dicyclohexyl-carbodiimide; In dichloromethane; for 18h; Ambient temperature;
DOI:10.1021/ja00075a008

Reference yield:

: 13031-04-4
ketopantolactone

: 152754-51-3
12-(benzyloxy)-12-oxo-1-dodecyl (2S)-1-(4-((benzyloxy)methoxy)-3,3-dimethyl-1,2-dioxobutyl)-2-piperidinecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 82 percent / 4-(dimethylamino)pyridine / toluene / 18 h / Heating

2: 89 percent / N,N-diisopropylethylamine / CH₂Cl₂ / 48 h / Ambient temperature

3: 100 percent / aq. LiOH / methanol / 3 h / Ambient temperature

4: 75 percent / 1,3-dicyclohexylcarbodiimide, 4-(dimethylamino)pyridine, 10-camphorsulfonic acid / CH₂Cl₂ / 18 h / Ambient temperature

With dmap; lithium hydroxide; (1S)-10-camphorsulfonic acid; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In methanol; dichloromethane; toluene;
DOI:10.1021/ja00075a008

Reference yield:

: 505-95-3
12-hydroxydodecanoic acid

: 152754-51-3
12-(benzyloxy)-12-oxo-1-dodecyl (2S)-1-(4-((benzyloxy)methoxy)-3,3-dimethyl-1,2-dioxobutyl)-2-piperidinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / potassium bicarbonate / dimethylformamide / 18 h / Ambient temperature

2: 75 percent / 1,3-dicyclohexylcarbodiimide, 4-(dimethylamino)pyridine, 10-camphorsulfonic acid / CH₂Cl₂ / 18 h / Ambient temperature

With dmap; (1S)-10-camphorsulfonic acid; potassium hydrogencarbonate; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja00075a008