(S)-1-{4-[2-(3-aminobenzyl)-1H-imidazol-1-yl]pyrimidin-2-ylamino}-propan-2-ol

Base Information

Chemical Name:(S)-1-{4-[2-(3-aminobenzyl)-1H-imidazol-1-yl]pyrimidin-2-ylamino}-propan-2-ol
CAS No.:1620069-22-8
Molecular Formula:C₁₇H₂₀N₆O
Molecular Weight:324.385
Hs Code.:

Synonyms:(S)-1-{4-[2-(3-aminobenzyl)-1H-imidazol-1-yl]pyrimidin-2-ylamino}-propan-2-ol

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Chemical Property of (S)-1-{4-[2-(3-aminobenzyl)-1H-imidazol-1-yl]pyrimidin-2-ylamino}-propan-2-ol

Chemical Property:

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Technology Process of (S)-1-{4-[2-(3-aminobenzyl)-1H-imidazol-1-yl]pyrimidin-2-ylamino}-propan-2-ol

There total 7 articles about (S)-1-{4-[2-(3-aminobenzyl)-1H-imidazol-1-yl]pyrimidin-2-ylamino}-propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1620069-21-7
(S)-1-(4-(2-(3-nitrobenzyl)-1H-imidazole-1-yl)pyrimidin-2-ylamino)propan-2-ol

: 1620069-22-8
(S)-1-{4-[2-(3-aminobenzyl)-1H-imidazol-1-yl]pyrimidin-2-ylamino}-propan-2-ol

Guidance literature:: With hydrogen; In methanol; at 20 ℃; for 3h;

Reference yield:

: ethyl 2-(3-nitrophenyl)acetimidate

: 1620069-22-8
(S)-1-{4-[2-(3-aminobenzyl)-1H-imidazol-1-yl]pyrimidin-2-ylamino}-propan-2-ol

Guidance literature:: Multi-step reaction with 6 steps

1: ethanol / 4 h / 40 °C

2: hydrogenchloride / water; methanol / 1 h / 90 °C

3: palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; potassium phosphate / toluene / 130 °C

4: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 20 °C

5: tetrahydrofuran / 6 h / 60 °C

6: hydrogen / methanol

With hydrogenchloride; potassium phosphate; hydrogen; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; toluene; 3: |Buchwald-Hartwig Coupling;
DOI:10.1016/j.bmcl.2014.05.030

Reference yield:

: 1523027-75-9
2-(3-nitrobenzyl)-1H-imidazole

: 1620069-22-8
(S)-1-{4-[2-(3-aminobenzyl)-1H-imidazol-1-yl]pyrimidin-2-ylamino}-propan-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1: palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; potassium phosphate / toluene / 130 °C

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 20 °C

3: tetrahydrofuran / 6 h / 60 °C

4: hydrogen / methanol

With potassium phosphate; hydrogen; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; dichloromethane; toluene; 1: |Buchwald-Hartwig Coupling;
DOI:10.1016/j.bmcl.2014.05.030