4-{6-[4-benzyloxy-2-(tert-butyldiphenylsilanyloxy)-butyl]-tetrahydropyran-2-yl}-3-oxobutyric acid ethyl ester

Base Information

Chemical Name:4-{6-[4-benzyloxy-2-(tert-butyldiphenylsilanyloxy)-butyl]-tetrahydropyran-2-yl}-3-oxobutyric acid ethyl ester
CAS No.:500208-47-9
Molecular Formula:C₃₈H₅₀O₆Si
Molecular Weight:630.897
Hs Code.:

Synonyms:4-{6-[4-benzyloxy-2-(tert-butyldiphenylsilanyloxy)-butyl]-tetrahydropyran-2-yl}-3-oxobutyric acid ethyl ester

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Chemical Property of 4-{6-[4-benzyloxy-2-(tert-butyldiphenylsilanyloxy)-butyl]-tetrahydropyran-2-yl}-3-oxobutyric acid ethyl ester

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Technology Process of 4-{6-[4-benzyloxy-2-(tert-butyldiphenylsilanyloxy)-butyl]-tetrahydropyran-2-yl}-3-oxobutyric acid ethyl ester

There total 3 articles about 4-{6-[4-benzyloxy-2-(tert-butyldiphenylsilanyloxy)-butyl]-tetrahydropyran-2-yl}-3-oxobutyric acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-{6-[4-benzyloxy-2-(tert-butyldiphenylsilanyloxy)-butyl]-2-hydroxytetrahydropyran-2-yl}-3-oxobutyric acid ethyl ester

: 500208-47-9
4-{6-[4-benzyloxy-2-(tert-butyldiphenylsilanyloxy)-butyl]-tetrahydropyran-2-yl}-3-oxobutyric acid ethyl ester

Guidance literature:: With triethylsilane; trifluoroacetic acid; In dichloromethane; at -30 ℃; for 4h;
DOI:10.1021/ol0272390

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 500208-47-9
4-{6-[4-benzyloxy-2-(tert-butyldiphenylsilanyloxy)-butyl]-tetrahydropyran-2-yl}-3-oxobutyric acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 85 percent / imidazole / dimethylformamide / 8 h / 20 °C

2.1: diisopropylamine; n-BuLi / tetrahydrofuran; hexane / -78 - 0 °C

2.2: tetrahydrofuran; hexane / 1 h / -78 °C

3.1: 278 g / triethylsilane; trifluoroacetic acid / CH₂Cl₂ / 4 h / -30 °C

With 1H-imidazole; triethylsilane; n-butyllithium; diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol0272390

Reference yield:

: 500208-43-5
6-[4-benzyloxy-2-(tert-butyldiphenylsilanyloxy)-butyl]-tetrahydropyran-2-one

: 500208-47-9
4-{6-[4-benzyloxy-2-(tert-butyldiphenylsilanyloxy)-butyl]-tetrahydropyran-2-yl}-3-oxobutyric acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: diisopropylamine; n-BuLi / tetrahydrofuran; hexane / -78 - 0 °C

1.2: tetrahydrofuran; hexane / 1 h / -78 °C

2.1: 278 g / triethylsilane; trifluoroacetic acid / CH₂Cl₂ / 4 h / -30 °C

With triethylsilane; n-butyllithium; diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/ol0272390