(4R)-cyclohexanecarbonyloxypyrrolidine-1,(2S)-dicarboxylic acid 2-allyl ester 1-tert-butyl ester

Base Information

• Chemical Name: (4R)-cyclohexanecarbonyloxypyrrolidine-1,(2S)-dicarboxylic acid 2-allyl ester 1-tert-butyl ester
• CAS No.: 1245657-00-4
• Molecular Formula: C₂₀H₃₁NO₆
• Molecular Weight: 381.469
• Mol file: 1245657-00-4.mol

Synonyms:(4R)-cyclohexanecarbonyloxypyrrolidine-1,(2S)-dicarboxylic acid 2-allyl ester 1-tert-butyl ester

Chemical Property of (4R)-cyclohexanecarbonyloxypyrrolidine-1,(2S)-dicarboxylic acid 2-allyl ester 1-tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4R)-cyclohexanecarbonyloxypyrrolidine-1,(2S)-dicarboxylic acid 2-allyl ester 1-tert-butyl ester

There total 1 articles about (4R)-cyclohexanecarbonyloxypyrrolidine-1,(2S)-dicarboxylic acid 2-allyl ester 1-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

(4R)-hydroxypyrrolidine-1,(2S)-dicarboxylic acid 2-allyl ester 1-tert-butyl ester (186320-37-6) + cyclohexanylcarbonyl chloride (2719-27-9) → (4R)-cyclohexanecarbonyloxypyrrolidine-1,(2S)-dicarboxylic acid 2-allyl ester 1-tert-butyl ester (1245657-00-4)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1021/jm100839w

Reference yield: 95.0%

(4R)-cyclohexanecarbonyloxypyrrolidine-1,(2S)-dicarboxylic acid 2-allyl ester 1-tert-butyl ester (1245657-00-4) → (4R)-cyclohexanecarbonyloxypyrrolidine-1,(2S)-dicarboxylic acid 1-tert-butyl ester (1245657-01-5)

Guidance literature:

With pyrrolidine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triphenylphosphine; In dichloromethane; at 20 ℃; for 0.666667h; Inert atmosphere;

DOI:10.1021/jm100839w

upstream raw materials:

(4R)-hydroxypyrrolidine-1,(2S)-dicarboxylic acid 2-allyl ester 1-tert-butyl ester

cyclohexanylcarbonyl chloride

Downstream raw materials:

(4R)-cyclohexanecarbonyloxypyrrolidine-1,(2S)-dicarboxylic acid 1-tert-butyl ester