1-[2-deoxy-5-O-(4-methoxytrityl)-α-D-erythro-pentofuranosyl]thymine

Base Information

• Chemical Name: 1-[2-deoxy-5-O-(4-methoxytrityl)-α-D-erythro-pentofuranosyl]thymine
• CAS No.: 52474-36-9
• Molecular Formula: C₃₀H₃₀N₂O₆
• Molecular Weight: 514.578
• Mol file: 52474-36-9.mol

Synonyms:1-[2-deoxy-5-O-(4-methoxytrityl)-α-D-erythro-pentofuranosyl]thymine

Chemical Property of 1-[2-deoxy-5-O-(4-methoxytrityl)-α-D-erythro-pentofuranosyl]thymine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[2-deoxy-5-O-(4-methoxytrityl)-α-D-erythro-pentofuranosyl]thymine

There total 3 articles about 1-[2-deoxy-5-O-(4-methoxytrityl)-α-D-erythro-pentofuranosyl]thymine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

mono-4-methoxytrityl chloride (14470-28-1) + α-deoxythymidine (4449-43-8,28854-96-8,3545-96-8,50-88-4) → 1-[2-deoxy-5-O-(4-methoxytrityl)-α-D-erythro-pentofuranosyl]thymine (52474-36-9)

Guidance literature:

In pyridine; at 20 ℃; for 16h;

DOI:10.1080/15257770008045467

Reference yield:

thymidine (50-89-5,28854-96-8,3545-96-8,50-88-4) → 1-[2-deoxy-5-O-(4-methoxytrityl)-α-D-erythro-pentofuranosyl]thymine (52474-36-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: chlorotrimethylsilane; hexamethyldisilazane; (NH₄)2SO₄ / 1.5 h / Heating

1.2: 26 percent / TMSOTl / acetonitrile / 1.5 h / Heating

2.1: 83 percent / pyridine / 16 h / 20 °C

With ammonium sulfate; chloro-trimethyl-silane; 1,1,1,3,3,3-hexamethyl-disilazane; In pyridine;

DOI:10.1080/15257770008045467

Reference yield:

→ 1-[2-deoxy-5-O-(4-methoxytrityl)-α-D-erythro-pentofuranosyl]thymine (52474-36-9)

Guidance literature:

α-Thymidin, Mono-p-methoxytritylchlorid;

DOI:10.1002/hlca.19740570108

upstream raw materials:

mono-4-methoxytrityl chloride

α-deoxythymidine

thymidine

Downstream raw materials:

C₄₈H₄₉N₄O₁₄P

C₅₅H₅₄N₅O₁₆P

1-[2-deoxy-3-O-(diethylphosphono)methyl-5-O-(4-methoxytrityl)-α-D-erythro-pentofuranosyl]thymine

Phosphoric acid (2S,3R,5S)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester dimethyl ester