(S)-2-{4-[2-(tert-butoxycarbonylamino)-2-carboxyethyl]phenoxy}ethyl 3β-hydroxyurs-12-en-28-oate

Base Information

Chemical Name:(S)-2-{4-[2-(tert-butoxycarbonylamino)-2-carboxyethyl]phenoxy}ethyl 3β-hydroxyurs-12-en-28-oate
CAS No.:1446690-35-2
Molecular Formula:C₄₆H₆₉NO₈
Molecular Weight:764.056
Hs Code.:

Synonyms:(S)-2-{4-[2-(tert-butoxycarbonylamino)-2-carboxyethyl]phenoxy}ethyl 3β-hydroxyurs-12-en-28-oate

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Chemical Property of (S)-2-{4-[2-(tert-butoxycarbonylamino)-2-carboxyethyl]phenoxy}ethyl 3β-hydroxyurs-12-en-28-oate

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Technology Process of (S)-2-{4-[2-(tert-butoxycarbonylamino)-2-carboxyethyl]phenoxy}ethyl 3β-hydroxyurs-12-en-28-oate

There total 3 articles about (S)-2-{4-[2-(tert-butoxycarbonylamino)-2-carboxyethyl]phenoxy}ethyl 3β-hydroxyurs-12-en-28-oate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 1446690-33-0
(S)-2-{4-[2-(tert-butoxycarbonylamino)-3-methoxy-3-oxopropyl]phenoxy}ethyl 3β-hydroxyurs-12-en-28-oate

: 1446690-35-2
(S)-2-{4-[2-(tert-butoxycarbonylamino)-2-carboxyethyl]phenoxy}ethyl 3β-hydroxyurs-12-en-28-oate

Guidance literature:: (S)-2-{4-[2-(tert-butoxycarbonylamino)-3-methoxy-3-oxopropyl]phenoxy}ethyl 3β-hydroxyurs-12-en-28-oate; With water; sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃;

With potassium hydrogensulfate; In tetrahydrofuran; methanol; water; at 20 ℃;
DOI:10.2174/157340613804488413

Reference yield:

: 4326-36-7
(S)-N-(tert-butoxycarbonyl)tyrosine methyl ester

: 1446690-35-2
(S)-2-{4-[2-(tert-butoxycarbonylamino)-2-carboxyethyl]phenoxy}ethyl 3β-hydroxyurs-12-en-28-oate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 18-crown-6 ether; potassium carbonate / 12 h / 80 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

3.1: sodium hydroxide; water / tetrahydrofuran; methanol / 20 °C

3.2: 20 °C

With 18-crown-6 ether; water; potassium carbonate; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.2174/157340613804488413

Reference yield:

: 1269631-36-8
(S)-methyl 3-(4-(2-bromoethoxy)phenyl)-2-((tert-butoxycarbonyl)amino)propanoate

: 1446690-35-2
(S)-2-{4-[2-(tert-butoxycarbonylamino)-2-carboxyethyl]phenoxy}ethyl 3β-hydroxyurs-12-en-28-oate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2.1: sodium hydroxide; water / tetrahydrofuran; methanol / 20 °C

2.2: 20 °C

With water; potassium carbonate; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.2174/157340613804488413