N-Allyl-N-benzyl-2-(tetrahydro-pyran-2-yloxymethyl)-benzamide

Base Information

• Chemical Name: N-Allyl-N-benzyl-2-(tetrahydro-pyran-2-yloxymethyl)-benzamide
• CAS No.: 211438-78-7
• Molecular Formula: C₂₃H₂₇NO₃
• Molecular Weight: 365.472
• Mol file: 211438-78-7.mol

Synonyms:N-Allyl-N-benzyl-2-(tetrahydro-pyran-2-yloxymethyl)-benzamide

Chemical Property of N-Allyl-N-benzyl-2-(tetrahydro-pyran-2-yloxymethyl)-benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-Allyl-N-benzyl-2-(tetrahydro-pyran-2-yloxymethyl)-benzamide

There total 8 articles about N-Allyl-N-benzyl-2-(tetrahydro-pyran-2-yloxymethyl)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

benzyl chloride (100-44-7) + N-Allyl-2-(tetrahydro-pyran-2-yloxymethyl)-benzamide (211438-68-5) → N-Allyl-N-benzyl-2-(tetrahydro-pyran-2-yloxymethyl)-benzamide (211438-78-7)

Guidance literature:

In N,N-dimethyl-formamide; at 40 ℃; for 6h;

DOI:10.1016/S0040-4039(98)00990-3

Reference yield: 80.0%

allyl bromide (106-95-6) + N-Benzyl-2-(tetrahydro-pyran-2-yloxymethyl)-benzamide (211438-70-9) → N-Allyl-N-benzyl-2-(tetrahydro-pyran-2-yloxymethyl)-benzamide (211438-78-7)

Guidance literature:

In N,N-dimethyl-formamide; at 40 ℃; for 6h;

DOI:10.1016/S0040-4039(98)00990-3

Reference yield:

phthalimide (136918-14-4,85-41-6) → N-Allyl-N-benzyl-2-(tetrahydro-pyran-2-yloxymethyl)-benzamide (211438-78-7)

Guidance literature:

Multi-step reaction with 4 steps

1: t-BuOK / dimethylformamide / 1 h / Ambient temperature

2: NaBH₄ / propan-2-ol; toluene; H₂O / 4 h / 0 °C

3: p-TsOH / CH₂Cl₂ / 2 h / Ambient temperature

4: 85 percent / dimethylformamide / 6 h / 40 °C

With sodium tetrahydroborate; potassium tert-butylate; toluene-4-sulfonic acid; In dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; toluene;

DOI:10.1016/S0040-4039(98)00990-3

upstream raw materials:

benzyl chloride

N-Allyl-2-(tetrahydro-pyran-2-yloxymethyl)-benzamide

allyl bromide

N-Benzyl-2-(tetrahydro-pyran-2-yloxymethyl)-benzamide

Downstream raw materials:

Allylbenzylamine