Technology Process of (2R)-6-azido-2-benzylhexanoyl-glycyl-glycine ethyl ester
There total 7 articles about (2R)-6-azido-2-benzylhexanoyl-glycyl-glycine ethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
at 20 ℃;
DOI:10.1021/jo001308b
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: NaN3 / dimethylformamide / 19 h / 20 °C
2.1: NaN(TMS)2 / tetrahydrofuran / 0.75 h / -78 °C
2.2: 54 percent / tetrahydrofuran / 2 h / 0 °C
3.1: 90 percent / LiOH; H2O2 / tetrahydrofuran; H2O / 0 - 20 °C
4.1: 43 percent / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; HOBt; Et3N / 20 °C
With
lithium hydroxide; sodium azide; dihydrogen peroxide; sodium hexamethyldisilazane; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
In
tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1021/jo001308b
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: NaN(TMS)2 / tetrahydrofuran / 0.75 h / -78 °C
1.2: 54 percent / tetrahydrofuran / 2 h / 0 °C
2.1: 90 percent / LiOH; H2O2 / tetrahydrofuran; H2O / 0 - 20 °C
3.1: 43 percent / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; HOBt; Et3N / 20 °C
With
lithium hydroxide; dihydrogen peroxide; sodium hexamethyldisilazane; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
In
tetrahydrofuran; water;
DOI:10.1021/jo001308b
