N-<3-(ethoxycarbonyl)-2-benzylidene-1-oxopropyl>glycine isopentylamide

Base Information

• Chemical Name: N-<3-(ethoxycarbonyl)-2-benzylidene-1-oxopropyl>glycine isopentylamide
• CAS No.: 96866-21-6
• Molecular Formula: C₂₀H₂₈N₂O₄
• Molecular Weight: 360.453
• Mol file: 96866-21-6.mol

Synonyms:N-<3-(ethoxycarbonyl)-2-benzylidene-1-oxopropyl>glycine isopentylamide

Chemical Property of N-<3-(ethoxycarbonyl)-2-benzylidene-1-oxopropyl>glycine isopentylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of N-<3-(ethoxycarbonyl)-2-benzylidene-1-oxopropyl>glycine isopentylamide

There total 1 articles about N-<3-(ethoxycarbonyl)-2-benzylidene-1-oxopropyl>glycine isopentylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

3-(ethoxycarbonyl)-2-benzylidenepropanoic acid (87439-00-7) + glycine isopentylamide trifluoroacetate (87429-14-9) → N-<3-(ethoxycarbonyl)-2-benzylidene-1-oxopropyl>glycine isopentylamide (96866-21-6)

Guidance literature:

With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; chloroform; Ambient temperature;

DOI:10.1021/jm00147a007

Reference yield: 76.0%

N-<3-(ethoxycarbonyl)-2-benzylidene-1-oxopropyl>glycine isopentylamide (96866-21-6) → N-(3-carboxy-2-benzylidene-1-oxopropyl)glycine isopentylamide (96866-22-7)

Guidance literature:

With sodium hydroxide; In ethanol; for 4h; Ambient temperature;

DOI:10.1021/jm00147a007

Reference yield:

N-<3-(ethoxycarbonyl)-2-benzylidene-1-oxopropyl>glycine isopentylamide (96866-21-6) → N-{3(RS)-[(hydroxyamino)carbonyl]-2-benzyl-1-oxopropyl}glycine isopentylamide (96896-86-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 76 percent / 1 N aq. NaOH / ethanol / 4 h / Ambient temperature

2: 81 percent / Et₃N, 1-hydroxybenzotriazol (HOBT), DCC / tetrahydrofuran; CHCl₃ / Ambient temperature

3: 97 percent / H₂ / 10percent Pd on charcoal / methanol / 3 h / Ambient temperature

With sodium hydroxide; hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; chloroform;

DOI:10.1021/jm00147a007

upstream raw materials:

3-(ethoxycarbonyl)-2-benzylidenepropanoic acid

glycine isopentylamide trifluoroacetate

Downstream raw materials:

N-(3-carboxy-2-benzylidene-1-oxopropyl)glycine isopentylamide

N-{3(RS)-[(hydroxyamino)carbonyl]-2-benzyl-1-oxopropyl}glycine isopentylamide

N-<3-<<(benzyloxy)amino>carbonyl>-2-benzylidene-1-oxopropyl>glycine isopenylamide