C₂₃H₂₄FNO₅

Base Information

• Chemical Name: C₂₃H₂₄FNO₅
• CAS No.: 1421237-15-1
• Molecular Formula: C₂₃H₂₄FNO₅
• Molecular Weight: 413.446
• Mol file: 1421237-15-1.mol

Synonyms:C₂₃H₂₄FNO₅

Chemical Property of C₂₃H₂₄FNO₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₃H₂₄FNO₅

There total 4 articles about C₂₃H₂₄FNO₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.8%

4-methoxy-3-(4-methylphenyl)-5H-furan-2-one (100074-66-6) + 3-fluoro-4-(4-morpholino)benzaldehyde (495404-90-5) → C23H24FNO5 (1421237-15-1)

Guidance literature:

With potassium carbonate; In methanol; at 20 ℃;

DOI:10.1016/j.bmcl.2012.11.090

Reference yield:

3-(4-methylphenyl)-4-hydroxyfuran-2(5H)-one (100074-53-1) → C23H24FNO5 (1421237-15-1)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetone / 20 °C / Inert atmosphere

2: potassium carbonate / methanol / 20 °C

With potassium carbonate; In methanol; acetone;

DOI:10.1016/j.bmcl.2012.11.090

Reference yield:

4-tolylacetic acid (622-47-9) → C23H24FNO5 (1421237-15-1)

Guidance literature:

Multi-step reaction with 4 steps

1: triethylamine / tetrahydrofuran / Reflux

2: potassium tert-butylate / N,N-dimethyl-formamide / 5.5 h / 0 - 20 °C

3: potassium carbonate / acetone / 20 °C / Inert atmosphere

4: potassium carbonate / methanol / 20 °C

With potassium tert-butylate; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetone;

DOI:10.1016/j.bmcl.2012.11.090

upstream raw materials:

4-tolylacetic acid

3-(4-methylphenyl)-4-hydroxyfuran-2(5H)-one

4-methoxy-3-(4-methylphenyl)-5H-furan-2-one

3-fluoro-4-(4-morpholino)benzaldehyde

Refernces