(2S,3S)-2-amino-N-((S)-1-hydroxy-3-phenyl-propan-2-yl)-3-methyl-pentanamide

Base Information

Chemical Name:(2S,3S)-2-amino-N-((S)-1-hydroxy-3-phenyl-propan-2-yl)-3-methyl-pentanamide
CAS No.:742675-58-7
Molecular Formula:C₁₅H₂₄N₂O₂
Molecular Weight:264.368
Hs Code.:

Synonyms:(2S,3S)-2-amino-N-((S)-1-hydroxy-3-phenyl-propan-2-yl)-3-methyl-pentanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3S)-2-amino-N-((S)-1-hydroxy-3-phenyl-propan-2-yl)-3-methyl-pentanamide

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Technology Process of (2S,3S)-2-amino-N-((S)-1-hydroxy-3-phenyl-propan-2-yl)-3-methyl-pentanamide

There total 4 articles about (2S,3S)-2-amino-N-((S)-1-hydroxy-3-phenyl-propan-2-yl)-3-methyl-pentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 111317-96-5
[(1S,2S)-1-((S)-1-Hydroxymethyl-2-phenyl-ethylcarbamoyl)-2-methyl-butyl]-carbamic acid benzyl ester

: 742675-58-7
(2S,3S)-2-amino-N-((S)-1-hydroxy-3-phenyl-propan-2-yl)-3-methyl-pentanamide

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃;
DOI:10.1021/acs.orglett.5b02514

Reference yield:

: 3182-95-4
L-Phenylalaninol

: 742675-58-7
(2S,3S)-2-amino-N-((S)-1-hydroxy-3-phenyl-propan-2-yl)-3-methyl-pentanamide

Guidance literature:: Multi-step reaction with 2 steps

1: HOBt, WSC / dimethylformamide / 14 h / Ambient temperature

2: H₂ / 5percent Pd/C / tetrahydrofuran; methanol / 3 h / 760 Torr / Ambient temperature

With hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm9803065

Reference yield:

: 6372-14-1
N-((benzyloxy)carbonyl)-L-phenylalaninol

: 742675-58-7
(2S,3S)-2-amino-N-((S)-1-hydroxy-3-phenyl-propan-2-yl)-3-methyl-pentanamide

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / 5percent Pd/C / tetrahydrofuran; methanol / 3 h / 760 Torr / Ambient temperature

2: HOBt, WSC / dimethylformamide / 14 h / Ambient temperature

3: H₂ / 5percent Pd/C / tetrahydrofuran; methanol / 3 h / 760 Torr / Ambient temperature

With hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm9803065