2-HYDROXY-4-PHENYLPYRIDINE

Base Information

• Chemical Name: 2-HYDROXY-4-PHENYLPYRIDINE
• CAS No.: 19006-81-6
• Molecular Formula: C11H9NO
• Molecular Weight: 171.199
• Hs Code.: 2933399090
• Mol file: 19006-81-6.mol

Synonyms:2(1H)-Pyridone,4-phenyl- (6CI,8CI);4-Phenyl-1H-pyridin-2-one;4-Phenyl-2(1H)-pyridinone;4-Phenyl-2-pyridinone;4-Phenyl-2-pyridone;4-Phenylpyridin-2-ol;

Chemical Property of 2-HYDROXY-4-PHENYLPYRIDINE

Chemical Property:

• Vapor Pressure: 1.94E-06mmHg at 25°C
• Melting Point: 229-231℃
• Refractive Index: 1.594
• Boiling Point: 394.7 °C at 760 mmHg
• PKA: 11?+-.0.10(Predicted)
• Flash Point: 232.8 °C
• PSA: 32.86000
• Density: 1.158 g/cm³
• LogP: 2.04190
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

4-Phenylpyridin-2-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-HYDROXY-4-PHENYLPYRIDINE

There total 15 articles about 2-HYDROXY-4-PHENYLPYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

(E)-3-phenylpropenal (14371-10-9) + cyanoacetic acid amide (107-91-5) → 4-phenylpyridin-2-one (19006-81-6)

Guidance literature:

With potassium tert-butylate; In dimethyl sulfoxide; at 90 ℃; for 4h;

DOI:10.1021/jo025546d

Reference yield: 64.0%

4-bromo-2-hydroxy pyridine + phenylboronic acid (98-80-6) → 4-phenylpyridin-2-ol (19006-81-6)

Guidance literature:

With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; at 90 ℃; for 72h;

Reference yield: 60.0%

4-Phenylpyridine 1-oxide (1131-61-9) → 4-phenylpyridin-2-ol (19006-81-6)

Guidance literature:

4-Phenylpyridine 1-oxide; With acetic anhydride; for 48h; Heating / reflux;

With sodium hydrogencarbonate; In water; ethyl acetate;

With potassium carbonate; In methanol; at 20 ℃; for 1h;

upstream raw materials:

(E)-3-phenylpropenal

N-carbamoylmethylpyridinium chloride

2-benzyloxy-6-chloro-4-phenyl-pyridine

4-chloro-2-hydroxypyridine

Downstream raw materials:

ethyl 4-methyl-2-(2-oxo-4-phenylpyridin-1(2H)-yl)thiazole-5-carboxylate

1-<2-cyano-1-(4-chlorophenyl)-ethenyl>4-phenyl-2(1H)-pyridinone

1-<2-cyano-1-(4-methoxyphenyl)-ethenyl>4-phenyl-2(1H)-pyridinone

2-methoxy-4-phenyl-pyridine

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