8-chloro-4-(2-cyclohexyl-6,7-dimethoxy-3-oxo-2,3-dihydroisoquinolin-4-yl)-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione

Base Information

Chemical Name:8-chloro-4-(2-cyclohexyl-6,7-dimethoxy-3-oxo-2,3-dihydroisoquinolin-4-yl)-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione
CAS No.:1426688-14-3
Molecular Formula:C₂₆H₂₆ClN₃O₅
Molecular Weight:495.963
Hs Code.:

Synonyms:8-chloro-4-(2-cyclohexyl-6,7-dimethoxy-3-oxo-2,3-dihydroisoquinolin-4-yl)-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione

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Chemical Property of 8-chloro-4-(2-cyclohexyl-6,7-dimethoxy-3-oxo-2,3-dihydroisoquinolin-4-yl)-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione

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Technology Process of 8-chloro-4-(2-cyclohexyl-6,7-dimethoxy-3-oxo-2,3-dihydroisoquinolin-4-yl)-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione

There total 3 articles about 8-chloro-4-(2-cyclohexyl-6,7-dimethoxy-3-oxo-2,3-dihydroisoquinolin-4-yl)-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 931-53-3
Cyclohexyl isocyanide

: 6280-88-2
4-chloro-2-nitro-benzoic acid

: 5680-79-5,883886-67-7
glycine ethyl ester hydrochloride

: 132628-76-3
2-(1,3-dioxolan-2-yl)-4,5-dimethoxybenzaldehyde

: 1426688-14-3
8-chloro-4-(2-cyclohexyl-6,7-dimethoxy-3-oxo-2,3-dihydroisoquinolin-4-yl)-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione

Guidance literature:: Cyclohexyl isocyanide; 4-chloro-2-nitro-benzoic acid; glycine ethyl ester hydrochloride; 2-(1,3-dioxolan-2-yl)-4,5-dimethoxybenzaldehyde; With sodium carbonate; In methanol; at 20 ℃; for 12h; Inert atmosphere;

With perchloric acid; In water; acetonitrile; at 20 ℃; for 8h; Inert atmosphere;

With acetic acid; zinc; In water; acetonitrile; at 60 ℃; for 8h; Inert atmosphere;
DOI:10.1021/co400001h

Reference yield:

: 103477-58-3
2-(2-bromo-4,5-dimethoxyphenyl)-1,3-dioxolane

: 1426688-14-3
8-chloro-4-(2-cyclohexyl-6,7-dimethoxy-3-oxo-2,3-dihydroisoquinolin-4-yl)-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran / -78 - -30 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: sodium carbonate / methanol / 12 h / 20 °C / Inert atmosphere

2.2: 8 h / 20 °C / Inert atmosphere

2.3: 8 h / 60 °C / Inert atmosphere

With n-butyllithium; sodium carbonate; In tetrahydrofuran; methanol; 2.1: |Ugi Condensation;
DOI:10.1021/co400001h

Reference yield:

: 5392-10-9
2-bromo-4,5-dimethoxybenzaldehyde

: 1426688-14-3
8-chloro-4-(2-cyclohexyl-6,7-dimethoxy-3-oxo-2,3-dihydroisoquinolin-4-yl)-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: toluene-4-sulfonic acid / toluene / 18 h / Reflux; Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran / -78 - -30 °C / Inert atmosphere

2.2: -78 - 20 °C / Inert atmosphere

3.1: sodium carbonate / methanol / 12 h / 20 °C / Inert atmosphere

3.2: 8 h / 20 °C / Inert atmosphere

3.3: 8 h / 60 °C / Inert atmosphere

With n-butyllithium; sodium carbonate; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; toluene; 3.1: |Ugi Condensation;
DOI:10.1021/co400001h