(R)-6,8-Bis(benzyloxymethoxy)-3-(tert-butyldimethylsilyloxy)-9-hydroxy-3-methyl-3,4-dihydroanthracen-1(2H)-one

Base Information

Chemical Name:(R)-6,8-Bis(benzyloxymethoxy)-3-(tert-butyldimethylsilyloxy)-9-hydroxy-3-methyl-3,4-dihydroanthracen-1(2H)-one
CAS No.:300719-56-6
Molecular Formula:C₃₇H₄₄O₇Si
Molecular Weight:628.838
Hs Code.:

Synonyms:(R)-6,8-Bis(benzyloxymethoxy)-3-(tert-butyldimethylsilyloxy)-9-hydroxy-3-methyl-3,4-dihydroanthracen-1(2H)-one

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Chemical Property of (R)-6,8-Bis(benzyloxymethoxy)-3-(tert-butyldimethylsilyloxy)-9-hydroxy-3-methyl-3,4-dihydroanthracen-1(2H)-one

Chemical Property:

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Technology Process of (R)-6,8-Bis(benzyloxymethoxy)-3-(tert-butyldimethylsilyloxy)-9-hydroxy-3-methyl-3,4-dihydroanthracen-1(2H)-one

There total 5 articles about (R)-6,8-Bis(benzyloxymethoxy)-3-(tert-butyldimethylsilyloxy)-9-hydroxy-3-methyl-3,4-dihydroanthracen-1(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 300719-37-3
(R)-5-(tert-Butyldimethylsilyloxy)-3-methoxy-5-methylhex-2-en-1-one

: 300719-60-2
Methyl 2,4-bis(benzyloxymethoxy)-6-methylbenzoate

: 300719-56-6
(R)-6,8-Bis(benzyloxymethoxy)-3-(tert-butyldimethylsilyloxy)-9-hydroxy-3-methyl-3,4-dihydroanthracen-1(2H)-one

Guidance literature:: Methyl 2,4-bis(benzyloxymethoxy)-6-methylbenzoate; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃; for 0.166667h;

(R)-5-(tert-Butyldimethylsilyloxy)-3-methoxy-5-methylhex-2-en-1-one; In tetrahydrofuran; hexane; at -70 - 20 ℃; for 0.75h;
DOI:10.1039/b003053h

Reference yield:

: 5-(tert-Butyldimethylsilyloxy)-3-methoxy-5-methylhex-2-en-1-one

: 300719-60-2
Methyl 2,4-bis(benzyloxymethoxy)-6-methylbenzoate

: (S)-6,8-Bis(benzyloxymethoxy)-3-(tert-butyldimethylsilyloxy)-9-hydroxy-3-methyl-3,4-dihydroanthracen-1(2H)-one

: 300719-56-6
(R)-6,8-Bis(benzyloxymethoxy)-3-(tert-butyldimethylsilyloxy)-9-hydroxy-3-methyl-3,4-dihydroanthracen-1(2H)-one

Guidance literature:: Methyl 2,4-bis(benzyloxymethoxy)-6-methylbenzoate; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃; for 0.166667h;

5-(tert-Butyldimethylsilyloxy)-3-methoxy-5-methylhex-2-en-1-one; In tetrahydrofuran; hexane; at -70 - 20 ℃; for 0.75h; Title compound not separated from byproducts;
DOI:10.1039/b003053h

Reference yield:

: 3587-60-8
Benzyloxymethyl chloride

: 300719-56-6
(R)-6,8-Bis(benzyloxymethoxy)-3-(tert-butyldimethylsilyloxy)-9-hydroxy-3-methyl-3,4-dihydroanthracen-1(2H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: 338 mg / Et₃N / tetrahydrofuran / 12 h / 20 °C

2.1: LDA / hexane; tetrahydrofuran / 0.17 h / -78 °C

2.2: hexane; tetrahydrofuran / 0.75 h / -70 - 20 °C

With triethylamine; lithium diisopropyl amide; In tetrahydrofuran; hexane; 1.1: Etherification / 2.1: Metallation / 2.2: Condensation;
DOI:10.1039/b003053h