benzyl (2S)-2-[3-[(tert-butoxycarbonyl)amino]propyl]-4-[2-(tert-butoxy)-2-oxoethyl]-3-oxo-3,4-dihydro-1(2H)-pyrazinecarboxylate

Base Information

Chemical Name:benzyl (2S)-2-[3-[(tert-butoxycarbonyl)amino]propyl]-4-[2-(tert-butoxy)-2-oxoethyl]-3-oxo-3,4-dihydro-1(2H)-pyrazinecarboxylate
CAS No.:247068-71-9
Molecular Formula:C₂₆H₃₇N₃O₇
Molecular Weight:503.596
Hs Code.:

Synonyms:benzyl (2S)-2-[3-[(tert-butoxycarbonyl)amino]propyl]-4-[2-(tert-butoxy)-2-oxoethyl]-3-oxo-3,4-dihydro-1(2H)-pyrazinecarboxylate

Suppliers and Price of benzyl (2S)-2-[3-[(tert-butoxycarbonyl)amino]propyl]-4-[2-(tert-butoxy)-2-oxoethyl]-3-oxo-3,4-dihydro-1(2H)-pyrazinecarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of benzyl (2S)-2-[3-[(tert-butoxycarbonyl)amino]propyl]-4-[2-(tert-butoxy)-2-oxoethyl]-3-oxo-3,4-dihydro-1(2H)-pyrazinecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of benzyl (2S)-2-[3-[(tert-butoxycarbonyl)amino]propyl]-4-[2-(tert-butoxy)-2-oxoethyl]-3-oxo-3,4-dihydro-1(2H)-pyrazinecarboxylate

There total 2 articles about benzyl (2S)-2-[3-[(tert-butoxycarbonyl)amino]propyl]-4-[2-(tert-butoxy)-2-oxoethyl]-3-oxo-3,4-dihydro-1(2H)-pyrazinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: tert-butyl 2-[[(2S)-2-[(benzyloxycarbonyl)amino]-5-[(tert-butoxycarbonyl)amino]pentanoyl](2,2-dimethoxyethyl)amino]acetate

: 247068-71-9
benzyl (2S)-2-[3-[(tert-butoxycarbonyl)amino]propyl]-4-[2-(tert-butoxy)-2-oxoethyl]-3-oxo-3,4-dihydro-1(2H)-pyrazinecarboxylate

Guidance literature:: With toluene-4-sulfonic acid; In toluene; at 75 ℃; for 4h;
DOI:10.1021/jm0004345

Reference yield:

: 7733-29-1,199924-46-4
Z-Orn(Boc)-OH

: 247068-71-9
benzyl (2S)-2-[3-[(tert-butoxycarbonyl)amino]propyl]-4-[2-(tert-butoxy)-2-oxoethyl]-3-oxo-3,4-dihydro-1(2H)-pyrazinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / EDC / CH₂Cl₂ / 2 h / 20 °C

2: 65 percent / p-toluenesulfonic acid monohydrate / toluene / 4 h / 75 °C

With toluene-4-sulfonic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; toluene;
DOI:10.1021/jm0004345

Reference yield:

: 247068-71-9
benzyl (2S)-2-[3-[(tert-butoxycarbonyl)amino]propyl]-4-[2-(tert-butoxy)-2-oxoethyl]-3-oxo-3,4-dihydro-1(2H)-pyrazinecarboxylate

: [4-[2-amino-3-(4-methoxy-phenyl)-propionyl]-3-(3-tert-butoxycarbonylamino-propyl)-2-oxo-piperazin-1-yl]-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 67 percent / H₂ / 10percent Pd/C / ethyl acetate / 2 h

2: 92 percent / EDC / CH₂Cl₂ / 1 h / 20 °C

3: H₂ / 10percent Pd/C / methanol / 0.5 h / 20 °C

With hydrogen; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 10percent Pd/C; In methanol; dichloromethane; ethyl acetate;
DOI:10.1021/jm0004345