2-cyclohexyl-2-prop-2-ynylmalonic acid dimethyl ester

Base Information

• Chemical Name: 2-cyclohexyl-2-prop-2-ynylmalonic acid dimethyl ester
• CAS No.: 906820-85-7
• Molecular Formula: C₁₄H₂₀O₄
• Molecular Weight: 252.31
• Mol file: 906820-85-7.mol

Synonyms:2-cyclohexyl-2-prop-2-ynylmalonic acid dimethyl ester

Chemical Property of 2-cyclohexyl-2-prop-2-ynylmalonic acid dimethyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2-cyclohexyl-2-prop-2-ynylmalonic acid dimethyl ester

There total 2 articles about 2-cyclohexyl-2-prop-2-ynylmalonic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

2-(3-oxocyclohexyl)-2-prop-2-ynylmalonic acid dimethyl ester (868388-66-3) → 2-cyclohexyl-2-prop-2-ynylmalonic acid dimethyl ester (906820-85-7)

Guidance literature:

2-(3-oxocyclohexyl)-2-prop-2-ynylmalonic acid dimethyl ester; With magnesium sulfate; benzenesufonyl hydrazide; In dichloromethane; at 20 ℃; for 24h;

With sodium cyanoborohydride; zinc(II) chloride; In methanol; for 18h; Heating;

DOI:10.1002/adsc.200505211

Reference yield:

dimethyl (prop-2-yn-1-yl)malonate (95124-07-5) → 2-cyclohexyl-2-prop-2-ynylmalonic acid dimethyl ester (906820-85-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 77 percent / DBU / tetrahydrofuran / 10 h / 20 °C

2.1: benzenesulfonohydrazide; MgSO₄ / CH₂Cl₂ / 24 h / 20 °C

2.2: 37 percent / sodium cyanoborohydride; zinc chloride / methanol / 18 h / Heating

With magnesium sulfate; 1,8-diazabicyclo[5.4.0]undec-7-ene; benzenesufonyl hydrazide; In tetrahydrofuran; dichloromethane;

DOI:10.1002/adsc.200505211

Reference yield:

2-cyclohexyl-2-prop-2-ynylmalonic acid dimethyl ester (906820-85-7) + thiophenol (108-98-5) → 3-exo-3-phenylsulfanylmethyloctahydroindene-1,1-dicarboxylic acid dimethyl ester + 3-endo-3-phenylsulfanylmethyloctahydroindene-1,1-dicarboxylic acid dimethyl ester

Guidance literature:

With 2,2'-azobis(isobutyronitrile); In tert-butyl alcohol; benzene; Heating;

DOI:10.1002/adsc.200505211

upstream raw materials:

2-(3-oxocyclohexyl)-2-prop-2-ynylmalonic acid dimethyl ester

dimethyl (prop-2-yn-1-yl)malonate