2-(4-NITROPHENYL)MALONDIALDEHYDE

Base Information

• Chemical Name: 2-(4-NITROPHENYL)MALONDIALDEHYDE
• CAS No.: 18915-53-2
• Molecular Formula: C9H7 N O4
• Molecular Weight: 193.159
• Hs Code.: 2913000090
• Mol file: 18915-53-2.mol

Synonyms:Malonaldehyde,(p-nitrophenyl)- (7CI,8CI); Propanedial, (4-nitrophenyl)- (9CI)

Chemical Property of 2-(4-NITROPHENYL)MALONDIALDEHYDE

Chemical Property:

• Vapor Pressure: 0.000138mmHg at 25°C
• Melting Point: 231-233(dec.)
• Refractive Index: 1.562
• Boiling Point: 333.3°C at 760 mmHg
• Flash Point: 164.5°C
• PSA: 79.96000
• Density: 1.323g/cm³
• LogP: 1.59940

Purity/Quality:

98%min ^*data from raw suppliers

2-(4-Nitrophenyl)malondialdehyde ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-NITROPHENYL)MALONDIALDEHYDE

There total 3 articles about 2-(4-NITROPHENYL)MALONDIALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

4-nitrobenzeneacetic acid (104-03-0) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 2-(4-nitrophenyl)-1,3-propanedial (18915-53-2)

Guidance literature:

N,N-dimethyl-formamide; With thionyl chloride; at 0 - 4 ℃; for 0.5h;

4-nitrobenzeneacetic acid; at 90 ℃; for 6h;

With sodium hydroxide; at 20 - 115 ℃; for 4h;

DOI:10.1039/c9ce00215d

Reference yield:

DNPM → 2-(4-nitrophenyl)-1,3-propanedial (18915-53-2)

Guidance literature:

With potassium hydroxide;

Reference yield:

4-nitrobenzeneacetic acid (104-03-0) → 2-(4-nitrophenyl)-1,3-propanedial (18915-53-2)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) POCl₃, (ii) NaClO₄

2: aq. KOH

With potassium hydroxide;

upstream raw materials:

4-nitrobenzeneacetic acid

N,N-dimethyl-formamide

Downstream raw materials:

6-Nitro-3-(4-nitro-phenyl)-10-thia-1,4a-diaza-anthracene 10,10-dioxide

4-(4-aminophenyl)-1H-pyrazole

4-(4-nitrophenyl)-1,2-oxazole

2-[(1E,3Z,5Z)-3-(4-nitrophenyl)-5-(3-propyl-1,3-benzothiazol-2-ylidene)penta-1,3-dienyl]-3-propyl-1,3-benzothiazol-3-ium iodide

Refernces

• 1、 Chen, Hsiang-Jung,Chew, Chee Ying,Chang, En-Hao,Tu, Yu-Wei,Wei, Li-Yu,Wu, Bo-Han,Chen, Chien-Hung,Yang, Ya-Ting,Huang, Su-Chin,Chen, Jen-Kun,Chen, I-Chia,Tan, Kui-Thong. "S - Cis Diene Conformation: A New Bathochromic Shift Strategy for Near-Infrared Fluorescence Switchable Dye and the Imaging Applications". supporting information. p. 5224 - 5234. Retrieved 2018/04/23.
• 2、 Xu, Shengjie,Li, Shenghui,Tang, Yonghe,Zhang, Jinchao,Wang, Shuxiang,Zhou, Chuanqi,Li, Xiaoliu. "Design, synthesis, and biologic evaluation of some novel N-arylpyrazole derivatives as cytotoxic agents". . p. 5610 - 5616. Retrieved 2013/12/04.