(S)-2-(4-nitro-N-(3-(4-(trifluoromethyl)phenyl)prop-2-ynyl)-phenylsulfonamido)-3-phenylpropanamide

Base Information

Chemical Name:(S)-2-(4-nitro-N-(3-(4-(trifluoromethyl)phenyl)prop-2-ynyl)-phenylsulfonamido)-3-phenylpropanamide
CAS No.:1386995-21-6
Molecular Formula:C₂₅H₂₀F₃N₃O₅S
Molecular Weight:531.512
Hs Code.:

Synonyms:(S)-2-(4-nitro-N-(3-(4-(trifluoromethyl)phenyl)prop-2-ynyl)-phenylsulfonamido)-3-phenylpropanamide

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Chemical Property of (S)-2-(4-nitro-N-(3-(4-(trifluoromethyl)phenyl)prop-2-ynyl)-phenylsulfonamido)-3-phenylpropanamide

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Technology Process of (S)-2-(4-nitro-N-(3-(4-(trifluoromethyl)phenyl)prop-2-ynyl)-phenylsulfonamido)-3-phenylpropanamide

There total 4 articles about (S)-2-(4-nitro-N-(3-(4-(trifluoromethyl)phenyl)prop-2-ynyl)-phenylsulfonamido)-3-phenylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 455-13-0
4-Iodobenzotrifluoride

: 1313239-32-5
(S)-2-(4-nitro-N-(prop-2-ynyl)phenylsulfonamido)-3-phenylpropanamide

: 1386995-21-6
(S)-2-(4-nitro-N-(3-(4-(trifluoromethyl)phenyl)prop-2-ynyl)-phenylsulfonamido)-3-phenylpropanamide

Guidance literature:: 4-Iodobenzotrifluoride; With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; at 20 ℃; for 0.5h; Inert atmosphere;

(S)-2-(4-nitro-N-(prop-2-ynyl)phenylsulfonamido)-3-phenylpropanamide; In tetrahydrofuran; Inert atmosphere;
DOI:10.1039/c2ob25111f

Reference yield:

: 1346635-27-5
(S)-2-(4-nitrophenylsulfonamido)-3-phenylpropanamide

: 1386995-21-6
(S)-2-(4-nitro-N-(3-(4-(trifluoromethyl)phenyl)prop-2-ynyl)-phenylsulfonamido)-3-phenylpropanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 10 h / 0 - 20 °C / Inert atmosphere

2.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / 0.5 h / 20 °C / Inert atmosphere

2.2: Inert atmosphere

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; triethylamine; In N,N-dimethyl-formamide; 2.1: Sonogashira coupling / 2.2: Sonogashira coupling;
DOI:10.1039/c2ob25111f

Reference yield:

: 5241-58-7
L-Phenylalanine amide

: 1386995-21-6
(S)-2-(4-nitro-N-(3-(4-(trifluoromethyl)phenyl)prop-2-ynyl)-phenylsulfonamido)-3-phenylpropanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

2.1: potassium carbonate / N,N-dimethyl-formamide / 10 h / 0 - 20 °C / Inert atmosphere

3.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / 0.5 h / 20 °C / Inert atmosphere

3.2: Inert atmosphere

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide; 3.1: Sonogashira coupling / 3.2: Sonogashira coupling;
DOI:10.1039/c2ob25111f