3,4-dihydro-2,2-dimethyl-6-fluoro-4-(4-methylbenzenesulphonylaminocarbonylamino)-2H-1-benzopyran

Base Information

• Chemical Name: 3,4-dihydro-2,2-dimethyl-6-fluoro-4-(4-methylbenzenesulphonylaminocarbonylamino)-2H-1-benzopyran
• CAS No.: 226923-00-8
• Molecular Formula: C₁₉H₂₁FN₂O₄S
• Molecular Weight: 392.451
• Mol file: 226923-00-8.mol

Synonyms:3,4-dihydro-2,2-dimethyl-6-fluoro-4-(4-methylbenzenesulphonylaminocarbonylamino)-2H-1-benzopyran

Chemical Property of 3,4-dihydro-2,2-dimethyl-6-fluoro-4-(4-methylbenzenesulphonylaminocarbonylamino)-2H-1-benzopyran

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,4-dihydro-2,2-dimethyl-6-fluoro-4-(4-methylbenzenesulphonylaminocarbonylamino)-2H-1-benzopyran

There total 7 articles about 3,4-dihydro-2,2-dimethyl-6-fluoro-4-(4-methylbenzenesulphonylaminocarbonylamino)-2H-1-benzopyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

Tosyl isocyanate (4083-64-1) + 4-amino-3,4-dihydro-2,2-dimethyl-6-fluoro-(2H)-1-benzopyran (226922-93-6) → 3,4-dihydro-2,2-dimethyl-6-fluoro-4-(4-methylbenzenesulphonylaminocarbonylamino)-2H-1-benzopyran (226923-00-8)

Guidance literature:

In dichloromethane; for 0.333333h;

DOI:10.1211/146080899128734587

Reference yield:

4-Fluorophenol (371-41-5) → 3,4-dihydro-2,2-dimethyl-6-fluoro-4-(4-methylbenzenesulphonylaminocarbonylamino)-2H-1-benzopyran (226923-00-8)

Guidance literature:

Multi-step reaction with 7 steps

1: conc. H₂SO₄

2: AlCl₃

3: pyrrolidine

4: NaBH₄ / methanol

5: 90 percent / conc. H₂SO₄ / -10 - 20 °C

6: 90 percent / conc. HCl / 10 h / Heating

7: 85 percent / CH₂Cl₂ / 0.33 h

With pyrrolidine; hydrogenchloride; sodium tetrahydroborate; aluminium trichloride; sulfuric acid; In methanol; dichloromethane; 2: Fries reaction / 5: Ritter reaction;

DOI:10.1211/146080899128734587

Reference yield:

4-fluorophenyl acetate (405-51-6) → 3,4-dihydro-2,2-dimethyl-6-fluoro-4-(4-methylbenzenesulphonylaminocarbonylamino)-2H-1-benzopyran (226923-00-8)

Guidance literature:

Multi-step reaction with 6 steps

1: AlCl₃

2: pyrrolidine

3: NaBH₄ / methanol

4: 90 percent / conc. H₂SO₄ / -10 - 20 °C

5: 90 percent / conc. HCl / 10 h / Heating

6: 85 percent / CH₂Cl₂ / 0.33 h

With pyrrolidine; hydrogenchloride; sodium tetrahydroborate; aluminium trichloride; sulfuric acid; In methanol; dichloromethane; 1: Fries reaction / 4: Ritter reaction;

DOI:10.1211/146080899128734587

upstream raw materials:

Tosyl isocyanate

4-amino-3,4-dihydro-2,2-dimethyl-6-fluoro-(2H)-1-benzopyran

4-Fluorophenol

4-fluorophenyl acetate