(S)-2-(azidomethyl)-1-benzyl-4,4-difluoropyrrolidine

Base Information

Chemical Name:(S)-2-(azidomethyl)-1-benzyl-4,4-difluoropyrrolidine
CAS No.:1318129-29-1
Molecular Formula:C₁₂H₁₄F₂N₄
Molecular Weight:252.267
Hs Code.:

Synonyms:(S)-2-(azidomethyl)-1-benzyl-4,4-difluoropyrrolidine

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Chemical Property of (S)-2-(azidomethyl)-1-benzyl-4,4-difluoropyrrolidine

Chemical Property:

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Technology Process of (S)-2-(azidomethyl)-1-benzyl-4,4-difluoropyrrolidine

There total 3 articles about (S)-2-(azidomethyl)-1-benzyl-4,4-difluoropyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1318129-12-2
(S)-(1-benzyl-4,4-difluoropyrrolidin-2-yl)methanol

: 1318129-29-1
(S)-2-(azidomethyl)-1-benzyl-4,4-difluoropyrrolidine

: 1318129-26-8
(R)-5-azido-1-benzyl-3,3-difluoropiperidine

Guidance literature:: With tetrabutylammoniun azide; ethanaminium,N-(difluoro-λ⁴-sulfanylidene)-N-ethyl-,tetrafluoroborate; In dichloromethane; at -78 ℃; for 4h;
DOI:10.1021/ol201769b

Reference yield:

: 1318130-03-8
(S)-methyl 4,4-difluoro-1-(phenylcarbonyl)pyrrolidine-2-carboxylate

: 1318129-29-1
(S)-2-(azidomethyl)-1-benzyl-4,4-difluoropyrrolidine

: 1318129-26-8
(R)-5-azido-1-benzyl-3,3-difluoropiperidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C / Reflux

1.2: 0 °C

2.1: tetrabutylammoniun azide; ethanaminium,N-(difluoro-λ⁴-sulfanylidene)-N-ethyl-,tetrafluoroborate / dichloromethane / 4 h / -78 °C

With lithium aluminium tetrahydride; tetrabutylammoniun azide; ethanaminium,N-(difluoro-λ⁴-sulfanylidene)-N-ethyl-,tetrafluoroborate; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol201769b

Reference yield:

: 169774-59-8
methyl (2S)-1-benzoyl-4-oxo-2-pyrrolidinecarboxylate

: 1318129-29-1
(S)-2-(azidomethyl)-1-benzyl-4,4-difluoropyrrolidine

: 1318129-26-8
(R)-5-azido-1-benzyl-3,3-difluoropiperidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: diethylamino-sulfur trifluoride / dichloromethane / 12 h / 0 - 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C / Reflux

2.2: 0 °C

3.1: tetrabutylammoniun azide; ethanaminium,N-(difluoro-λ⁴-sulfanylidene)-N-ethyl-,tetrafluoroborate / dichloromethane / 4 h / -78 °C

With lithium aluminium tetrahydride; diethylamino-sulfur trifluoride; tetrabutylammoniun azide; ethanaminium,N-(difluoro-λ⁴-sulfanylidene)-N-ethyl-,tetrafluoroborate; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol201769b