4-iodobenzaldehyde hydrazone

Base Information

• Chemical Name: 4-iodobenzaldehyde hydrazone
• CAS No.: 860680-36-0
• Molecular Formula: C₇H₇IN₂
• Molecular Weight: 246.05
• Mol file: 860680-36-0.mol

Synonyms:4-iodobenzaldehyde hydrazone

Chemical Property of 4-iodobenzaldehyde hydrazone

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 4-iodobenzaldehyde hydrazone

There total 1 articles about 4-iodobenzaldehyde hydrazone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

p-(iodophenyl)carboxaldehyde (15164-44-0) → 4-iodobenzaldehyde hydrazone (860680-36-0)

Guidance literature:

With hydrazine hydrate; In methanol; at 20 ℃; for 1h;

DOI:10.1002/anie.201611067

Reference yield: 81.0%

carbon dioxide (124-38-9,18923-20-1) + 4-iodobenzaldehyde hydrazone (860680-36-0) → (4-iodophenyl)acetic acid (1798-06-7)

Guidance literature:

With 1,1'-bis-(diphenylphosphino)ferrocene; [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; caesium carbonate; cesium fluoride; In N,N-dimethyl-formamide; at 80 ℃; for 24h; under 760.051 Torr; chemoselective reaction;

DOI:10.1039/c8sc01299g

Reference yield:

Ethyl trichloroacetate (515-84-4) + 4-iodobenzaldehyde hydrazone (860680-36-0) → ethyl (E)-2-chloro-3-(4-iodophenyl)acrylate + ethyl (Z)-2-chloro-3-(4-iodophenyl)acrylate

Guidance literature:

With triethylamine; CuCl₂*2H₂O; In dimethyl sulfoxide; at 20 ℃; for 24h; Title compound not separated from byproducts;

DOI:10.1055/s-2004-815951

upstream raw materials:

p-(iodophenyl)carboxaldehyde

Downstream raw materials:

1-azido-4-iodobenzene

(4-iodophenyl)acetic acid

Refernces

• 1、 Nenajdenko, Valentine G.,Lenkova, Olesya N.,Shastin, Alexey V.,Balenkova, Elizabeth S.. "New synthetic approach to α-chlorocinnamates: First example of synthesis of functionally substituted alkenes using catalytic olefination reaction". . p. 573 - 577. Retrieved 2007/10/03.