3-(N-methylanilino)-1-{4-[2-(1,2,3,4-tetrahydroacridin-9-ylamino)ethyl]-piperazino}-1-propanone

Base Information

• Chemical Name: 3-(N-methylanilino)-1-{4-[2-(1,2,3,4-tetrahydroacridin-9-ylamino)ethyl]-piperazino}-1-propanone
• CAS No.: 1400765-62-9
• Molecular Formula: C₂₉H₃₇N₅O
• Molecular Weight: 471.646

Synonyms:3-(N-methylanilino)-1-{4-[2-(1,2,3,4-tetrahydroacridin-9-ylamino)ethyl]-piperazino}-1-propanone

Chemical Property of 3-(N-methylanilino)-1-{4-[2-(1,2,3,4-tetrahydroacridin-9-ylamino)ethyl]-piperazino}-1-propanone

Chemical Property:

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Technology Process of 3-(N-methylanilino)-1-{4-[2-(1,2,3,4-tetrahydroacridin-9-ylamino)ethyl]-piperazino}-1-propanone

There total 4 articles about 3-(N-methylanilino)-1-{4-[2-(1,2,3,4-tetrahydroacridin-9-ylamino)ethyl]-piperazino}-1-propanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

3-chloro-1-{4-[2-(1,2,3,4-tetrahydroacridin-9-ylamino)ethyl]piperazino}-1-propanone (1400765-56-1) + N-methylaniline (100-61-8) → 3-(N-methylanilino)-1-{4-[2-(1,2,3,4-tetrahydroacridin-9-ylamino)ethyl]-piperazino}-1-propanone (1400765-62-9)

Guidance literature:

With potassium carbonate; In ethanol; acetone; Reflux;

DOI:10.1016/j.ejmech.2012.06.051

Reference yield:

9-chloro-1,2,3,4-tetrahydroacridine (5396-30-5) → 3-(N-methylanilino)-1-{4-[2-(1,2,3,4-tetrahydroacridin-9-ylamino)ethyl]-piperazino}-1-propanone (1400765-62-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: phenol / 4 h / Reflux

1.2: 1.5 h

1.3: 0.25 h

2.1: ammonia; triethylamine / 1 h / 0 °C

3.1: potassium carbonate / ethanol; acetone / Reflux

With ammonia; potassium carbonate; triethylamine; In ethanol; acetone; phenol;

DOI:10.1016/j.ejmech.2012.06.051

Reference yield:

4-(2-aminoethyl)piperazine-1-carboxylic acid (91441-53-1) → 3-(N-methylanilino)-1-{4-[2-(1,2,3,4-tetrahydroacridin-9-ylamino)ethyl]-piperazino}-1-propanone (1400765-62-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: phenol / 4 h / Reflux

1.2: 1.5 h

1.3: 0.25 h

2.1: ammonia; triethylamine / 1 h / 0 °C

3.1: potassium carbonate / ethanol; acetone / Reflux

With ammonia; potassium carbonate; triethylamine; In ethanol; acetone; phenol;

DOI:10.1016/j.ejmech.2012.06.051

upstream raw materials:

3-chloro-1-{4-[2-(1,2,3,4-tetrahydroacridin-9-ylamino)ethyl]piperazino}-1-propanone

N-methylaniline

9-chloro-1,2,3,4-tetrahydroacridine

4-(2-aminoethyl)piperazine-1-carboxylic acid

Downstream raw materials:

N-(2-{4-[3-(methylanilino)propyl]piperazino}ethyl)-(1,2,3,4-tetrahydroacridin-9-yl)amine

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