methyl 2-(5-methyl-6-(4-(methylsulfonyl)phenylsulfonyl)-6H-thieno[2,3-b]pyrrol-4-yl)acetate

Base Information

Chemical Name:methyl 2-(5-methyl-6-(4-(methylsulfonyl)phenylsulfonyl)-6H-thieno[2,3-b]pyrrol-4-yl)acetate
CAS No.:1179808-91-3
Molecular Formula:C₁₇H₁₇NO₆S₃
Molecular Weight:427.523
Hs Code.:

Synonyms:methyl 2-(5-methyl-6-(4-(methylsulfonyl)phenylsulfonyl)-6H-thieno[2,3-b]pyrrol-4-yl)acetate

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Chemical Property of methyl 2-(5-methyl-6-(4-(methylsulfonyl)phenylsulfonyl)-6H-thieno[2,3-b]pyrrol-4-yl)acetate

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Technology Process of methyl 2-(5-methyl-6-(4-(methylsulfonyl)phenylsulfonyl)-6H-thieno[2,3-b]pyrrol-4-yl)acetate

There total 3 articles about methyl 2-(5-methyl-6-(4-(methylsulfonyl)phenylsulfonyl)-6H-thieno[2,3-b]pyrrol-4-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 70651-00-2
methyl 2-(5-methyl-6H-thieno[2,3-b]pyrrol-4-yl)acetate

: 82964-91-8
4-methylsulfinylbenzenesulfonyl chloride

: 1179808-91-3
methyl 2-(5-methyl-6-(4-(methylsulfonyl)phenylsulfonyl)-6H-thieno[2,3-b]pyrrol-4-yl)acetate

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; at 20 ℃; for 1h;

Reference yield:

: C₁₅H₂₀BrNO₄S

: 1179808-91-3
methyl 2-(5-methyl-6-(4-(methylsulfonyl)phenylsulfonyl)-6H-thieno[2,3-b]pyrrol-4-yl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: palladium diacetate; triphenylphosphine / 85 °C

2.1: silica gel / 85 °C

3.1: potassium tert-butylate / tetrahydrofuran / 0 °C

3.2: 20 °C

With potassium tert-butylate; palladium diacetate; silica gel; triphenylphosphine; In tetrahydrofuran; 1.1: intramolecular Heck cyclization;
DOI:10.1016/j.bmcl.2011.01.008

Reference yield:

: 1179808-94-6
tert-Butyl 4-(2-methoxy-2-oxoethyl)-5-methyl-6H-thieno[2,3-b]pyrrole-6-carboxylate

: 1179808-91-3
methyl 2-(5-methyl-6-(4-(methylsulfonyl)phenylsulfonyl)-6H-thieno[2,3-b]pyrrol-4-yl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: silica gel / 85 °C

2.1: potassium tert-butylate / tetrahydrofuran / 0 °C

2.2: 20 °C

With potassium tert-butylate; silica gel; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2011.01.008