tert-butyl 2-(4-fluoroanilino)-4-vinylbenzoate

Base Information

• Chemical Name: tert-butyl 2-(4-fluoroanilino)-4-vinylbenzoate
• CAS No.: 910240-70-9
• Molecular Formula: C₁₉H₂₀FNO₂
• Molecular Weight: 313.372
• Mol file: 910240-70-9.mol

Synonyms:tert-butyl 2-(4-fluoroanilino)-4-vinylbenzoate

Chemical Property of tert-butyl 2-(4-fluoroanilino)-4-vinylbenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 2-(4-fluoroanilino)-4-vinylbenzoate

There total 5 articles about tert-butyl 2-(4-fluoroanilino)-4-vinylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 4-bromo-2-(4-fluoroanilino)benzoate (910240-68-5) + pinacol vinylboronate (75927-49-0) → tert-butyl 2-(4-fluoroanilino)-4-vinylbenzoate (910240-70-9)

Guidance literature:

With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; at 20 ℃; for 4h; Heating / reflux;

Reference yield:

tert-butyl 2-amino-4-bromobenzoate (890315-73-8) → tert-butyl 2-(4-fluoroanilino)-4-vinylbenzoate (910240-70-9)

Guidance literature:

Multi-step reaction with 2 steps

1: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / palladium diacetate / toluene / 14 h / 20 °C / Heating / reflux

2: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 4 h / 20 °C / Heating / reflux

With potassium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium diacetate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; toluene;

Reference yield:

tert-butyl 4-bromo-2-nitrobenzoate (890315-72-7) → tert-butyl 2-(4-fluoroanilino)-4-vinylbenzoate (910240-70-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: iron; acetic acid / methanol / 1 h / Heating / reflux

1.2: 20 °C

2.1: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / palladium diacetate / toluene / 14 h / 20 °C / Heating / reflux

3.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 4 h / 20 °C / Heating / reflux

With iron; potassium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; acetic acid; palladium diacetate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; 1,2-dimethoxyethane; water; toluene;

upstream raw materials:

tert-butyl 4-bromo-2-(4-fluoroanilino)benzoate

pinacol vinylboronate

tert-butyl 2-amino-4-bromobenzoate

tert-butyl 4-bromo-2-nitrobenzoate