dimethyl N-<4-<<(2,4-diaminoquinazolin-5-yl)methyl>amino>benzoyl>-L-glutamate

Base Information

• Chemical Name: dimethyl N-<4-<<(2,4-diaminoquinazolin-5-yl)methyl>amino>benzoyl>-L-glutamate
• CAS No.: 161201-03-2
• Molecular Formula: C₂₃H₂₆N₆O₅
• Molecular Weight: 466.497
• Mol file: 161201-03-2.mol

Synonyms:dimethyl N-<4-<<(2,4-diaminoquinazolin-5-yl)methyl>amino>benzoyl>-L-glutamate

Chemical Property of dimethyl N-<4-<<(2,4-diaminoquinazolin-5-yl)methyl>amino>benzoyl>-L-glutamate

Chemical Property:

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Technology Process of dimethyl N-<4-<<(2,4-diaminoquinazolin-5-yl)methyl>amino>benzoyl>-L-glutamate

There total 1 articles about dimethyl N-<4-<<(2,4-diaminoquinazolin-5-yl)methyl>amino>benzoyl>-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

dimethyl N-(4-amino-benzoyl)-L-glutamate (52407-60-0) + 2,4-diaminoquinazoline-5-carbonitrile (137553-45-8) → dimethyl N-<4-<<(2,4-diaminoquinazolin-5-yl)methyl>amino>benzoyl>-L-glutamate (161201-03-2)

Guidance literature:

With hydrogen; sodium acetate; nickel; In acetic acid; for 6h; under 2585.7 Torr;

DOI:10.1021/jm00005a002

Reference yield: 71.0%

dimethyl N-<4-<<(2,4-diaminoquinazolin-5-yl)methyl>amino>benzoyl>-L-glutamate (161201-03-2) → N-<4-<<(2,4-diaminoquinazolin-5-yl)methyl>amino>benzoyl>-L-glutamic acid

Guidance literature:

With barium dihydroxide; In methanol; water;

DOI:10.1021/jm00005a002

Reference yield: 30.0%

3,4,5-trimethoxyphenylacetylene (53560-33-1) + dimethyl N-<4-<<(2,4-diaminoquinazolin-5-yl)methyl>amino>benzoyl>-L-glutamate (161201-03-2) → 2,4-diamino-5-<2-(3',4',5'-trimethoxyphenyl)ethynyl>quinazoline

Guidance literature:

With copper(l) iodide; triethylamine; triphenylphosphine; palladium dichloride; In acetonitrile; for 18h; Heating;

DOI:10.1021/jm00005a002

upstream raw materials:

dimethyl N-(4-amino-benzoyl)-L-glutamate

2,4-diaminoquinazoline-5-carbonitrile