2-benzyloxycarbonylamino-N-benzyloxycarbonylmethyl-malonamic acid

Base Information

• Chemical Name: 2-benzyloxycarbonylamino-N-benzyloxycarbonylmethyl-malonamic acid
• CAS No.: 350238-00-5
• Molecular Formula: C₂₀H₂₀N₂O₇
• Molecular Weight: 400.388
• Mol file: 350238-00-5.mol

Synonyms:2-benzyloxycarbonylamino-N-benzyloxycarbonylmethyl-malonamic acid

Chemical Property of 2-benzyloxycarbonylamino-N-benzyloxycarbonylmethyl-malonamic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-benzyloxycarbonylamino-N-benzyloxycarbonylmethyl-malonamic acid

There total 3 articles about 2-benzyloxycarbonylamino-N-benzyloxycarbonylmethyl-malonamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2-benzyloxycarbonylamino-N-benzyloxycarbonylmethyl-malonamic acid tert-butyl ester (350238-16-3) → 2-benzyloxycarbonylamino-N-benzyloxycarbonylmethyl-malonamic acid (350238-00-5)

Guidance literature:

With trifluoroacetic acid; In dichloromethane;

DOI:10.1016/S0040-4039(01)00402-6

Reference yield:

Gly-OBz (1738-68-7) → 2-benzyloxycarbonylamino-N-benzyloxycarbonylmethyl-malonamic acid (350238-00-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 66 percent / EDCl; HOBT

2: 83 percent / TFA / CH₂Cl₂

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane;

DOI:10.1016/S0040-4039(01)00402-6

Reference yield:

mono-t-butyl ester of N-benzyloxycarbonylaminomalonic acid (84245-57-8) → 2-benzyloxycarbonylamino-N-benzyloxycarbonylmethyl-malonamic acid (350238-00-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 66 percent / EDCl; HOBT

2: 83 percent / TFA / CH₂Cl₂

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane;

DOI:10.1016/S0040-4039(01)00402-6

upstream raw materials:

2-benzyloxycarbonylamino-N-benzyloxycarbonylmethyl-malonamic acid tert-butyl ester

Gly-OBz

mono-t-butyl ester of N-benzyloxycarbonylaminomalonic acid

Downstream raw materials:

{2-Benzyloxycarbonylamino-2-[5-chloro-2-(2-phenylcarbamoyl-acetyl)-phenylcarbamoyl]-acetylamino}-acetic acid benzyl ester