(Z)-(2S,3S)-3-{[((1R,3S)-1-Benzyloxymethyl-8-hydroxy-1,2,3,4-tetrahydro-isoquinolin-3-yl)-cyano-methyl]-amino}-2-morpholin-4-yl-7-trimethylsilanyl-hept-5-enenitrile

Base Information

Chemical Name:(Z)-(2S,3S)-3-{[((1R,3S)-1-Benzyloxymethyl-8-hydroxy-1,2,3,4-tetrahydro-isoquinolin-3-yl)-cyano-methyl]-amino}-2-morpholin-4-yl-7-trimethylsilanyl-hept-5-enenitrile
CAS No.:872607-53-9
Molecular Formula:C₃₃H₄₅N₅O₃Si
Molecular Weight:587.837
Hs Code.:

(Z)-(2S,3S)-3-{[((1R,3S)-1-Benzyloxymethyl-8-hydroxy-1,2,3,4-tetrahydro-isoquinolin-3-yl)-cyano-methyl]-amino}-2-morpholin-4-yl-7-trimethylsilanyl-hept-5-enenitrile

Synonyms:(Z)-(2S,3S)-3-{[((1R,3S)-1-Benzyloxymethyl-8-hydroxy-1,2,3,4-tetrahydro-isoquinolin-3-yl)-cyano-methyl]-amino}-2-morpholin-4-yl-7-trimethylsilanyl-hept-5-enenitrile

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Chemical Property of (Z)-(2S,3S)-3-{[((1R,3S)-1-Benzyloxymethyl-8-hydroxy-1,2,3,4-tetrahydro-isoquinolin-3-yl)-cyano-methyl]-amino}-2-morpholin-4-yl-7-trimethylsilanyl-hept-5-enenitrile

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Technology Process of (Z)-(2S,3S)-3-{[((1R,3S)-1-Benzyloxymethyl-8-hydroxy-1,2,3,4-tetrahydro-isoquinolin-3-yl)-cyano-methyl]-amino}-2-morpholin-4-yl-7-trimethylsilanyl-hept-5-enenitrile

There total 17 articles about (Z)-(2S,3S)-3-{[((1R,3S)-1-Benzyloxymethyl-8-hydroxy-1,2,3,4-tetrahydro-isoquinolin-3-yl)-cyano-methyl]-amino}-2-morpholin-4-yl-7-trimethylsilanyl-hept-5-enenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (Z)-(2S,3S)-3-{[1-((1R,3S)-1-Benzyloxymethyl-8-hydroxy-1,2,3,4-tetrahydro-isoquinolin-3-yl)-meth-(E)-ylidene]-amino}-2-morpholin-4-yl-7-trimethylsilanyl-hept-5-enenitrile

: 151-50-8
potassium cyanide

: 872607-53-9
(Z)-(2S,3S)-3-{[((1R,3S)-1-Benzyloxymethyl-8-hydroxy-1,2,3,4-tetrahydro-isoquinolin-3-yl)-cyano-methyl]-amino}-2-morpholin-4-yl-7-trimethylsilanyl-hept-5-enenitrile

Guidance literature:: potassium cyanide; With acetic acid; In methanol; for 0.166667h; cooling;

(Z)-(2S,3S)-3-{[1-((1R,3S)-1-Benzyloxymethyl-8-hydroxy-1,2,3,4-tetrahydro-isoquinolin-3-yl)-meth-(E)-ylidene]-amino}-2-morpholin-4-yl-7-trimethylsilanyl-hept-5-enenitrile; In methanol; dichloromethane; at 0 ℃; for 2h;
DOI:10.1021/ja056206n

Reference yield:

: 872607-59-5
(S)-2-Amino-6-trimethylsilanyl-hex-4-yn-1-ol

: 872607-53-9
(Z)-(2S,3S)-3-{[((1R,3S)-1-Benzyloxymethyl-8-hydroxy-1,2,3,4-tetrahydro-isoquinolin-3-yl)-cyano-methyl]-amino}-2-morpholin-4-yl-7-trimethylsilanyl-hept-5-enenitrile

Guidance literature:: Multi-step reaction with 9 steps

1.1: 98 percent / triethylamine / tetrahydrofuran / 1 h / 23 °C

2.1: 90 percent / sodim borohydride; Ni(OAc)2*4H₂O; ethylenediamine / ethanol / 3 h / 23 °C

3.1: Dess-Martin periodinane / CH₂Cl₂ / 0.67 h / 0 °C

4.1: acetic acid / methanol / 0.17 h / cooling

4.2: methanol; CH₂Cl₂ / 5 h / 0 °C

5.1: 2,2,2-trifluoro-ethanol / 14 h / 23 °C

6.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / CH₂Cl₂ / 1 h / 0 - 23 °C

7.1: sodium sulfate / benzene; CH₂Cl₂ / 2 h / 23 °C

8.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / CH₂Cl₂ / 0.17 h / cooling

9.1: acetic acid / methanol / 0.17 h / cooling

9.2: 23.6 mg / methanol; CH₂Cl₂ / 2 h / 0 °C

With sodium tetrahydroborate; nickel diacetate; Dess-Martin periodane; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium sulfate; ethylenediamine; triethylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane; 2,2,2-trifluoroethanol; benzene;
DOI:10.1021/ja056206n

Reference yield:

: 872607-62-0
(Z)-(2S,3S)-3-Amino-2-morpholin-4-yl-7-trimethylsilanyl-hept-5-enenitrile

: 872607-53-9
(Z)-(2S,3S)-3-{[((1R,3S)-1-Benzyloxymethyl-8-hydroxy-1,2,3,4-tetrahydro-isoquinolin-3-yl)-cyano-methyl]-amino}-2-morpholin-4-yl-7-trimethylsilanyl-hept-5-enenitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium sulfate / benzene; CH₂Cl₂ / 2 h / 23 °C

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / CH₂Cl₂ / 0.17 h / cooling

3.1: acetic acid / methanol / 0.17 h / cooling

3.2: 23.6 mg / methanol; CH₂Cl₂ / 2 h / 0 °C

With acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium sulfate; In methanol; dichloromethane; benzene;
DOI:10.1021/ja056206n