3-iodo-N₁-(2-methyl-4-(perfluoropropan-2-yl)phenyl)-N₂-(prop-2-yn-1-yl)phthalamide

Base Information

• Chemical Name: 3-iodo-N₁-(2-methyl-4-(perfluoropropan-2-yl)phenyl)-N₂-(prop-2-yn-1-yl)phthalamide
• CAS No.: 1629909-40-5
• Molecular Formula: C₂₁H₁₄F₇IN₂O₂
• Molecular Weight: 586.248

Synonyms:3-iodo-N₁-(2-methyl-4-(perfluoropropan-2-yl)phenyl)-N₂-(prop-2-yn-1-yl)phthalamide

Chemical Property of 3-iodo-N₁-(2-methyl-4-(perfluoropropan-2-yl)phenyl)-N₂-(prop-2-yn-1-yl)phthalamide

Chemical Property:

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Technology Process of 3-iodo-N₁-(2-methyl-4-(perfluoropropan-2-yl)phenyl)-N₂-(prop-2-yn-1-yl)phthalamide

There total 2 articles about 3-iodo-N₁-(2-methyl-4-(perfluoropropan-2-yl)phenyl)-N₂-(prop-2-yn-1-yl)phthalamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

2-methyl-4-(heptafluoropropan-2-yl)-aniline (238098-26-5) + 3-iodo-2-(prop-2-yn-1-ylcarbamoyl)benzoic acid (1629909-42-7) → 3-iodo-N1-(2-methyl-4-(perfluoropropan-2-yl)phenyl)-N2-(prop-2-yn-1-yl)phthalamide (1629909-40-5)

Guidance literature:

3-iodo-2-(prop-2-yn-1-ylcarbamoyl)benzoic acid; With trifluoroacetic anhydride; In toluene; at 20 ℃; for 0.5h;

2-methyl-4-(heptafluoropropan-2-yl)-aniline; With trifluoroacetic acid; In acetonitrile; for 1h; Cooling with ice;

DOI:10.1002/cjoc.201400202

Reference yield:

3-iodophthalic anhydride (28418-88-4) → 3-iodo-N1-(2-methyl-4-(perfluoropropan-2-yl)phenyl)-N2-(prop-2-yn-1-yl)phthalamide (1629909-40-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: acetonitrile / 20 °C

2.1: trifluoroacetic anhydride / toluene / 0.5 h / 20 °C

2.2: 1 h / Cooling with ice

With trifluoroacetic anhydride; In toluene; acetonitrile;

DOI:10.1002/cjoc.201400202

Reference yield:

3-trifluoromethylphenylazide (22001-17-8) + 3-iodo-N1-(2-methyl-4-(perfluoropropan-2-yl)phenyl)-N2-(prop-2-yn-1-yl)phthalamide (1629909-40-5) → 3-iodo-N1-(2-methyl-4-(perfluoropropan-2-yl)phenyl)-N2-((1-(3-(trifluoromethyl)phenyl)-1H-1,2,3-triazol-4-yl)methyl)phthalamide (1629909-21-2)

Guidance literature:

With copper(l) iodide; triethylamine; at 20 ℃;

DOI:10.1002/cjoc.201400202

upstream raw materials:

2-methyl-4-(heptafluoropropan-2-yl)-aniline

3-iodo-2-(prop-2-yn-1-ylcarbamoyl)benzoic acid

3-iodophthalic anhydride

Downstream raw materials:

3-iodo-N¹-(2-methyl-4-(perfluoropropan-2-yl)phenyl)-N²-((1-phenyl-1H-1,2,3-triazol-4-yl)methyl)phthalamide

3-iodo-N¹-(2-methyl-4-(perfluoropropan-2-yl)phenyl)-N²-((1-(p-tolyl)-1H-1,2,3-triazol-4-yl)methyl)phthalamide

3-iodo-N¹-(2-methyl-4-(perfluoropropan-2-yl)phenyl)-N²-((1-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl)methyl)phthalamide

3-iodo-N¹-(2-methyl-4-(perfluoropropan-2-yl)phenyl)-N²-((1-(4-nitrophenyl)-1H-1,2,3-triazol-4-yl)methyl)phthalamide

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