TC-SP 14

Base Information

Chemical Name:TC-SP 14
CAS No.:1257093-40-5
Molecular Formula:C₂₅H₂₀F₂N₂O₂S
Molecular Weight:450.509
Hs Code.:
Mol file:1257093-40-5.mol

Synonyms:1-(3-fluoro-4-(5-(2-fluorobenzyl)benzo[d]thiazol-2-yl)benzyl)azetidine-3-carboxylic acid

Suppliers and Price of TC-SP 14

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
TC-SP 14
10mg
$ 480.00

TRC
1-[[3-Fluoro-4-[5-[(2-fluorophenyl)methyl]-2-benzothiazolyl]phenyl]methyl]-3-azetidinecarboxylicAcid
50mg
$ 760.00

Tocris
TC-SP14 ≥98%(HPLC)
10
$ 178.00

Tocris
TC-SP14 ≥98%(HPLC)
50
$ 746.00

ApexBio Technology
TC-SP14
50mg
$ 1425.00

American Custom Chemicals Corporation
TC-SP-14 98.00%
5MG
$ 496.67

Total 2 raw suppliers

Chemical Property of TC-SP 14

Chemical Property:

Solubility.:<22.52mg/ml in DMSO

Purity/Quality:

≥98% by HPLC ^*data from raw suppliers

TC-SP 14 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses 1-[[3-Fluoro-4-[5-[(2-fluorophenyl)methyl]-2-benzothiazolyl]phenyl]methyl]-3-azetidinecarboxylic Acid is a potent Sphingosine-1-Phosphate Receptor 1 (S1P1) agonist with minimal activity at S1P3. It has been shown to attenuate DTH response to antigen challenge while significantly reducing blood lymphocyte counts.

Technology Process of TC-SP 14

There total 7 articles about TC-SP 14 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1257093-54-1
C₂₆H₂₂F₂N₂O₂S

: 1257093-40-5
1-(3-fluoro-4-(5-(2-fluorobenzyl)benzo[d]thiazol-2-yl)benzyl)azetidine-3-carboxylic acid

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran;
DOI:10.1021/ml100228m

Reference yield:

: 1257093-52-9
C₁₇H₁₃BrFNO₂S

: 1257093-40-5
1-(3-fluoro-4-(5-(2-fluorobenzyl)benzo[d]thiazol-2-yl)benzyl)azetidine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride / tetrahydrofuran; water / 55 °C

2: sodium cyanoborohydride; acetic acid; N-ethyl-N,N-diisopropylamine / methanol; dichloromethane

3: bis(di-tert-butyl(phenyl)phosphine) palladium dichloride / tetrahydrofuran

4: water; lithium hydroxide / tetrahydrofuran

With hydrogenchloride; bis(di-tert-butyl(phenyl)phosphine) palladium dichloride; water; sodium cyanoborohydride; acetic acid; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; 3: Negishi coupling reaction;
DOI:10.1021/ml100228m

Reference yield:

: 1257093-73-4
C₁₄H₇BrFNOS

: 1257093-40-5
1-(3-fluoro-4-(5-(2-fluorobenzyl)benzo[d]thiazol-2-yl)benzyl)azetidine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: sodium cyanoborohydride; acetic acid; N-ethyl-N,N-diisopropylamine / methanol; dichloromethane

2: bis(di-tert-butyl(phenyl)phosphine) palladium dichloride / tetrahydrofuran

3: water; lithium hydroxide / tetrahydrofuran

With bis(di-tert-butyl(phenyl)phosphine) palladium dichloride; water; sodium cyanoborohydride; acetic acid; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; 2: Negishi coupling reaction;
DOI:10.1021/ml100228m