TC-SP 14

Base Information

• Chemical Name: TC-SP 14
• CAS No.: 1257093-40-5
• Molecular Formula: C₂₅H₂₀F₂N₂O₂S
• Molecular Weight: 450.509
• Mol file: 1257093-40-5.mol

Synonyms:1-(3-fluoro-4-(5-(2-fluorobenzyl)benzo[d]thiazol-2-yl)benzyl)azetidine-3-carboxylic acid

Chemical Property of TC-SP 14

Chemical Property:

• Solubility.: <22.52mg/ml in DMSO

Purity/Quality:

98.5% ^*data from raw suppliers

TC-SP 14 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 1-[[3-Fluoro-4-[5-[(2-fluorophenyl)methyl]-2-benzothiazolyl]phenyl]methyl]-3-azetidinecarboxylic Acid is a potent Sphingosine-1-Phosphate Receptor 1 (S1P1) agonist with minimal activity at S1P3. It has been shown to attenuate DTH response to antigen challenge while significantly reducing blood lymphocyte counts.

Technology Process of TC-SP 14

There total 7 articles about TC-SP 14 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

C26H22F2N2O2S (1257093-54-1) → 1-(3-fluoro-4-(5-(2-fluorobenzyl)benzo[d]thiazol-2-yl)benzyl)azetidine-3-carboxylic acid (1257093-40-5)

Guidance literature:

With water; lithium hydroxide; In tetrahydrofuran;

DOI:10.1021/ml100228m

Reference yield:

C17H13BrFNO2S (1257093-52-9) → 1-(3-fluoro-4-(5-(2-fluorobenzyl)benzo[d]thiazol-2-yl)benzyl)azetidine-3-carboxylic acid (1257093-40-5)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrogenchloride / tetrahydrofuran; water / 55 °C

2: sodium cyanoborohydride; acetic acid; N-ethyl-N,N-diisopropylamine / methanol; dichloromethane

3: bis(di-tert-butyl(phenyl)phosphine) palladium dichloride / tetrahydrofuran

4: water; lithium hydroxide / tetrahydrofuran

With hydrogenchloride; bis(di-tert-butyl(phenyl)phosphine) palladium dichloride; water; sodium cyanoborohydride; acetic acid; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; 3: Negishi coupling reaction;

DOI:10.1021/ml100228m

Reference yield:

C14H7BrFNOS (1257093-73-4) → 1-(3-fluoro-4-(5-(2-fluorobenzyl)benzo[d]thiazol-2-yl)benzyl)azetidine-3-carboxylic acid (1257093-40-5)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium cyanoborohydride; acetic acid; N-ethyl-N,N-diisopropylamine / methanol; dichloromethane

2: bis(di-tert-butyl(phenyl)phosphine) palladium dichloride / tetrahydrofuran

3: water; lithium hydroxide / tetrahydrofuran

With bis(di-tert-butyl(phenyl)phosphine) palladium dichloride; water; sodium cyanoborohydride; acetic acid; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; 2: Negishi coupling reaction;

DOI:10.1021/ml100228m

upstream raw materials:

2-(4-bromo-3-fluorophenyl)-1,3-dioxane

2-fluoro-5-bromophenyl isothiocyanate

C₁₇H₁₃BrFNO₂S

C₁₉H₁₆BrFN₂O₂S

Refernces