N-(4-Chlorobenzyl)-7-[2-(diethylamino)ethyl]-2-(3-hydroxy-1-propynyl)-4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamide hydrochloride

Base Information

Chemical Name:N-(4-Chlorobenzyl)-7-[2-(diethylamino)ethyl]-2-(3-hydroxy-1-propynyl)-4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamide hydrochloride
CAS No.:292143-81-8
Molecular Formula:C₂₄H₂₆ClN₃O₃S*ClH
Molecular Weight:508.469
Hs Code.:

Synonyms:N-(4-Chlorobenzyl)-7-[2-(diethylamino)ethyl]-2-(3-hydroxy-1-propynyl)-4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamide hydrochloride

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Chemical Property of N-(4-Chlorobenzyl)-7-[2-(diethylamino)ethyl]-2-(3-hydroxy-1-propynyl)-4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamide hydrochloride

Chemical Property:

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Technology Process of N-(4-Chlorobenzyl)-7-[2-(diethylamino)ethyl]-2-(3-hydroxy-1-propynyl)-4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamide hydrochloride

There total 6 articles about N-(4-Chlorobenzyl)-7-[2-(diethylamino)ethyl]-2-(3-hydroxy-1-propynyl)-4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 292143-61-4,863101-96-6
N-((4-chlorophenyl)methyl)-4-hydroxy-2-(3-hydroxy-1-propynyl)thieno[2,3-b]pyridine-5-carboxamide

: 1069-72-3
2-bromo-N,N-diethylethanamine hydrobromide

: 292143-81-8
N-(4-Chlorobenzyl)-7-[2-(diethylamino)ethyl]-2-(3-hydroxy-1-propynyl)-4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamide hydrochloride

Guidance literature:: With potassium carbonate; In water; methanol hydrochloride; N,N-dimethyl-formamide;

Reference yield:

: 292143-52-3,863101-95-5
N-(4-chlorobenzyl)-4-hydroxy-2-iodothieno[2,3-b]pyridine-5-carboxamide

: 292143-81-8
N-(4-Chlorobenzyl)-7-[2-(diethylamino)ethyl]-2-(3-hydroxy-1-propynyl)-4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamide hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: Pd(PPh₃)2Cl₂ / diethylamine

2: potassium carbonate / water; methanol hydrochloride; N,N-dimethyl-formamide

With potassium carbonate; Pd(PPh₃)2Cl₂; In water; methanol hydrochloride; diethylamine; N,N-dimethyl-formamide;

Reference yield:

: 4-hydroxy-2-iodothieno[2,3-b]pyridine-5-carboxylic acid

: 292143-81-8
N-(4-Chlorobenzyl)-7-[2-(diethylamino)ethyl]-2-(3-hydroxy-1-propynyl)-4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide

2: Pd(PPh₃)2Cl₂ / diethylamine

3: potassium carbonate / water; methanol hydrochloride; N,N-dimethyl-formamide

With potassium carbonate; 1,1'-carbonyldiimidazole; Pd(PPh₃)2Cl₂; In water; methanol hydrochloride; diethylamine; N,N-dimethyl-formamide;