Nγ-(5-tert-butyldiphenylsilyl-2,3-di-O-acetyl-α-D-ribosyl)-N-α-benzyloxycarbonyl asparagine benzyl ester

Base Information

Chemical Name:Nγ-(5-tert-butyldiphenylsilyl-2,3-di-O-acetyl-α-D-ribosyl)-N-α-benzyloxycarbonyl asparagine benzyl ester
CAS No.:1220340-27-1
Molecular Formula:C₄₄H₅₀N₂O₁₁Si
Molecular Weight:810.973
Hs Code.:

Synonyms:Nγ-(5-tert-butyldiphenylsilyl-2,3-di-O-acetyl-α-D-ribosyl)-N-α-benzyloxycarbonyl asparagine benzyl ester

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Chemical Property of Nγ-(5-tert-butyldiphenylsilyl-2,3-di-O-acetyl-α-D-ribosyl)-N-α-benzyloxycarbonyl asparagine benzyl ester

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Technology Process of Nγ-(5-tert-butyldiphenylsilyl-2,3-di-O-acetyl-α-D-ribosyl)-N-α-benzyloxycarbonyl asparagine benzyl ester

There total 4 articles about Nγ-(5-tert-butyldiphenylsilyl-2,3-di-O-acetyl-α-D-ribosyl)-N-α-benzyloxycarbonyl asparagine benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1461715-84-3
N^δ-(5-tert-butyldiphenylsilyl-α-D-ribosyl)-N^α-benzyloxycarbonylasparagine benzyl ester

: 108-24-7
acetic anhydride

: 1220340-27-1
Nγ-(5-tert-butyldiphenylsilyl-2,3-di-O-acetyl-α-D-ribosyl)-N-α-benzyloxycarbonyl asparagine benzyl ester

Guidance literature:: With pyridine; dmap; In dichloromethane; at 20 ℃; for 24h;
DOI:10.3390/molecules18088779

Reference yield:

: C₂₅H₃₃NO₆Si

: 4779-31-1
Z-Asp-OBn

: 1220340-27-1
Nγ-(5-tert-butyldiphenylsilyl-2,3-di-O-acetyl-α-D-ribosyl)-N-α-benzyloxycarbonyl asparagine benzyl ester

: 1220340-49-7
Nγ-(5-tert-butyldiphenylsilyl-2,3-di-O-acetyl-β-D-ribosyl)-N-α-benzyloxycarbonyl asparagine benzyl ester

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 4h; optical yield given as %de; Inert atmosphere;
DOI:10.1021/ja910940q

Reference yield:

: 1461715-82-1
1-benzyl 5-[2-(diphenylphosphanyl)-4-fluorophenyl]-N-(benzyloxycarbonyl)-L-aspartate

: 1220340-27-1
Nγ-(5-tert-butyldiphenylsilyl-2,3-di-O-acetyl-α-D-ribosyl)-N-α-benzyloxycarbonyl asparagine benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; N,N-dimethyl acetamide / 20 h / 20 - 70 °C

1.2: 2 h / 70 °C

2.1: dmap; pyridine / dichloromethane / 24 h / 20 °C

With pyridine; dmap; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; N,N-dimethyl acetamide; In dichloromethane;
DOI:10.3390/molecules18088779