6-amino-1-[2,6-dimethyl-4-(3-morpholin-4-yl-propoxy)-phenyl]-3,4-dihydro-1H-quinazolin-2-one

Base Information

Chemical Name:6-amino-1-[2,6-dimethyl-4-(3-morpholin-4-yl-propoxy)-phenyl]-3,4-dihydro-1H-quinazolin-2-one
CAS No.:678173-29-0
Molecular Formula:C₂₃H₃₀N₄O₃
Molecular Weight:410.516
Hs Code.:

6-amino-1-[2,6-dimethyl-4-(3-morpholin-4-yl-propoxy)-phenyl]-3,4-dihydro-1<i>H</i>-quinazolin-2-one

Synonyms:6-amino-1-[2,6-dimethyl-4-(3-morpholin-4-yl-propoxy)-phenyl]-3,4-dihydro-1H-quinazolin-2-one

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Chemical Property of 6-amino-1-[2,6-dimethyl-4-(3-morpholin-4-yl-propoxy)-phenyl]-3,4-dihydro-1H-quinazolin-2-one

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Technology Process of 6-amino-1-[2,6-dimethyl-4-(3-morpholin-4-yl-propoxy)-phenyl]-3,4-dihydro-1H-quinazolin-2-one

There total 6 articles about 6-amino-1-[2,6-dimethyl-4-(3-morpholin-4-yl-propoxy)-phenyl]-3,4-dihydro-1H-quinazolin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 678173-28-9
1-[2,6-dimethyl-4-(3-morpholin-4-yl-propoxy)-phenyl]-6-nitro-3,4-dihydro-1H-quinazolin-2-one

: 678173-29-0
6-amino-1-[2,6-dimethyl-4-(3-morpholin-4-yl-propoxy)-phenyl]-3,4-dihydro-1H-quinazolin-2-one

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 16h;
DOI:10.1016/j.bmcl.2003.11.006

Reference yield:

: 7357-67-7
4-(3-chloropropyl)morpholine

: 678173-29-0
6-amino-1-[2,6-dimethyl-4-(3-morpholin-4-yl-propoxy)-phenyl]-3,4-dihydro-1H-quinazolin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 49 percent / CsI / dimethylformamide / 16 h / 130 °C

2: 98 percent / H₂ / Pd/C / methanol / 16 h / 20 °C

With isocyanate de chlorosulfonyle; hydrogen; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2003.11.006

Reference yield:

: 175696-39-6
4-(tert-Butyl-dimethyl-silanyloxy)-2,6-dimethyl-phenylamine

: 678173-29-0
6-amino-1-[2,6-dimethyl-4-(3-morpholin-4-yl-propoxy)-phenyl]-3,4-dihydro-1H-quinazolin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 59 percent / DMAP / CH₂Cl₂ / 16 h / 20 - 40 °C

2: 92 percent / 2-(dicyclohexylphosphino)biphenyl; K₃PO₄; Pd₂dba3 / dimethylformamide / 16 h / 135 °C

3: 49 percent / CsI / dimethylformamide / 16 h / 130 °C

4: 98 percent / H₂ / Pd/C / methanol / 16 h / 20 °C

With dmap; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; isocyanate de chlorosulfonyle; hydrogen; CyJohnPhos; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2003.11.006