Technology Process of MeOC6H3ICH(NHBoc)CONHCH(CH3)COOH
There total 6 articles about MeOC6H3ICH(NHBoc)CONHCH(CH3)COOH which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
lithium hydroxide;
In
tetrahydrofuran;
DOI:10.1021/ja073340u
- Guidance literature:
-
Multi-step reaction with 5 steps
1: sodium hydrogencarbonate / acetone; water
2: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0 - 20 °C
3: potassium carbonate / acetone / 17 h / Inert atmosphere; Reflux
4: silver sulfate; iodine / methanol / 0.5 h
5: lithium hydroxide / water; tetrahydrofuran
With
iodine; sodium hydrogencarbonate; potassium carbonate; benzotriazol-1-ol; silver sulfate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hydroxide;
In
tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetone;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: sodium hydrogencarbonate / acetone; water
2: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0 - 20 °C
3: potassium carbonate / acetone / 17 h / Inert atmosphere; Reflux
4: silver sulfate; iodine / methanol / 0.5 h
5: lithium hydroxide / water; tetrahydrofuran
With
iodine; sodium hydrogencarbonate; potassium carbonate; benzotriazol-1-ol; silver sulfate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hydroxide;
In
tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetone;
