2-(4-((2R,3R,4R,5S)-3,4,5-tris(benzyloxy)-2-((benzyloxy)methyl)piperidin-1-yl)butyl)isoindoline-1,3-dione

Base Information

Chemical Name:2-(4-((2R,3R,4R,5S)-3,4,5-tris(benzyloxy)-2-((benzyloxy)methyl)piperidin-1-yl)butyl)isoindoline-1,3-dione
CAS No.:1450832-94-6
Molecular Formula:C₄₆H₄₈N₂O₆
Molecular Weight:724.897
Hs Code.:

Synonyms:2-(4-((2R,3R,4R,5S)-3,4,5-tris(benzyloxy)-2-((benzyloxy)methyl)piperidin-1-yl)butyl)isoindoline-1,3-dione

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Chemical Property of 2-(4-((2R,3R,4R,5S)-3,4,5-tris(benzyloxy)-2-((benzyloxy)methyl)piperidin-1-yl)butyl)isoindoline-1,3-dione

Chemical Property:

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Technology Process of 2-(4-((2R,3R,4R,5S)-3,4,5-tris(benzyloxy)-2-((benzyloxy)methyl)piperidin-1-yl)butyl)isoindoline-1,3-dione

There total 1 articles about 2-(4-((2R,3R,4R,5S)-3,4,5-tris(benzyloxy)-2-((benzyloxy)methyl)piperidin-1-yl)butyl)isoindoline-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 5394-18-3
2-(4-bromobutyl)isoindoline-1,3-dione

: 69567-11-9,76738-52-8,126836-30-4
2,3,4,6-tetra-O-benzyl-1,5-dideoxy-1,5-imino-D-glucitol

: 1450832-94-6
2-(4-((2R,3R,4R,5S)-3,4,5-tris(benzyloxy)-2-((benzyloxy)methyl)piperidin-1-yl)butyl)isoindoline-1,3-dione

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 100 ℃; for 6h;
DOI:10.1016/j.bmc.2013.06.054

Reference yield: 87.0%

: 1450832-94-6
2-(4-((2R,3R,4R,5S)-3,4,5-tris(benzyloxy)-2-((benzyloxy)methyl)piperidin-1-yl)butyl)isoindoline-1,3-dione

: 1450832-95-7
4-((2R,3R,4R,5S)-3,4,5-tris(benzyloxy)-2-((benzyloxy)methyl)piperidin-1-yl)butan-1-amine

Guidance literature:: With hydrazine hydrate; In ethanol; for 3h; Reflux;
DOI:10.1016/j.bmc.2013.06.054

Reference yield:

: 1450832-94-6
2-(4-((2R,3R,4R,5S)-3,4,5-tris(benzyloxy)-2-((benzyloxy)methyl)piperidin-1-yl)butyl)isoindoline-1,3-dione

: (2R,3R,4R,5S)-3,4,5-tris(benzyloxy)-2-((benzyloxy)methyl)-1-(4-(pyrrolidin-1-yl)butyl)piperidine

Guidance literature:: Multi-step reaction with 2 steps

1: hydrazine hydrate / ethanol / 3 h / Reflux

2: potassium carbonate / acetonitrile / 12 h / 80 °C

With potassium carbonate; hydrazine hydrate; In ethanol; acetonitrile;
DOI:10.17344/acsi.2019.5778