(2R,5S)-1-benzyloxycarbonyl-4-tert-butoxycarbonyl-2,5-dimethylpiperazine

Base Information

Chemical Name:(2R,5S)-1-benzyloxycarbonyl-4-tert-butoxycarbonyl-2,5-dimethylpiperazine
CAS No.:548762-65-8
Molecular Formula:C₁₉H₂₈N₂O₄
Molecular Weight:348.442
Hs Code.:

Synonyms:(2R,5S)-1-benzyloxycarbonyl-4-tert-butoxycarbonyl-2,5-dimethylpiperazine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,5S)-1-benzyloxycarbonyl-4-tert-butoxycarbonyl-2,5-dimethylpiperazine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

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Technology Process of (2R,5S)-1-benzyloxycarbonyl-4-tert-butoxycarbonyl-2,5-dimethylpiperazine

There total 7 articles about (2R,5S)-1-benzyloxycarbonyl-4-tert-butoxycarbonyl-2,5-dimethylpiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 548762-64-7
(2R,5S)-1-benzyloxycarbonyl-2,5-dimethylpiperazine

: 548762-65-8
(2R,5S)-1-benzyloxycarbonyl-4-tert-butoxycarbonyl-2,5-dimethylpiperazine

Guidance literature:: In dichloromethane; at 0 - 20 ℃;
DOI:10.1021/jo0300385

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 548762-65-8
(2R,5S)-1-benzyloxycarbonyl-4-tert-butoxycarbonyl-2,5-dimethylpiperazine

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / aqueous NaHCO₃ / CHCl₃ / 4 h / 20 °C

2: 100 percent / hydrogen; glacial acetic acid / Pd/C / H₂O / 3 h / Heating

3: 98 percent / CH₂Cl₂ / 0 - 20 °C

With hydrogen; sodium hydrogencarbonate; acetic acid; palladium on activated charcoal; In dichloromethane; chloroform; water;
DOI:10.1021/jo0300385

Reference yield:

: 155836-79-6
(+)-(2S,5R)-1-allyl-2,5-dimethylpiperazine

: 548762-65-8
(2R,5S)-1-benzyloxycarbonyl-4-tert-butoxycarbonyl-2,5-dimethylpiperazine

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / aqueous NaHCO₃ / CHCl₃ / 4 h / 20 °C

2: 100 percent / hydrogen; glacial acetic acid / Pd/C / H₂O / 3 h / Heating

3: 98 percent / CH₂Cl₂ / 0 - 20 °C

With hydrogen; sodium hydrogencarbonate; acetic acid; palladium on activated charcoal; In dichloromethane; chloroform; water;
DOI:10.1021/jo0300385