(S)-3-((S)-(4-tert-butylphenyl)(hydroxy)methyl)-4-iodo-2-isopropyl-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-5-ol

Base Information

Chemical Name:(S)-3-((S)-(4-tert-butylphenyl)(hydroxy)methyl)-4-iodo-2-isopropyl-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-5-ol
CAS No.:1332491-49-2
Molecular Formula:C₂₅H₃₄INO₂
Molecular Weight:507.455
Hs Code.:

Synonyms:(S)-3-((S)-(4-tert-butylphenyl)(hydroxy)methyl)-4-iodo-2-isopropyl-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-5-ol

Suppliers and Price of (S)-3-((S)-(4-tert-butylphenyl)(hydroxy)methyl)-4-iodo-2-isopropyl-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-5-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-3-((S)-(4-tert-butylphenyl)(hydroxy)methyl)-4-iodo-2-isopropyl-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-5-ol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-3-((S)-(4-tert-butylphenyl)(hydroxy)methyl)-4-iodo-2-isopropyl-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-5-ol

There total 10 articles about (S)-3-((S)-(4-tert-butylphenyl)(hydroxy)methyl)-4-iodo-2-isopropyl-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-5-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1332490-06-8
(S)-5-hydroxy-4-iodo-2-isopropyl-7,7-dimethyl-5,6,7,8-tetrahydroquinoline-3-carbaldehyde

: 63488-10-8
4-tert-butylmagnesium bromide

: 1332486-60-8
(S)-3-((R)-(4-tert-butylphenyl)(hydroxy)methyl)-4-iodo-2-isopropyl-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-5-ol

: 1332491-49-2
(S)-3-((S)-(4-tert-butylphenyl)(hydroxy)methyl)-4-iodo-2-isopropyl-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-5-ol

Guidance literature:: (S)-5-hydroxy-4-iodo-2-isopropyl-7,7-dimethyl-5,6,7,8-tetrahydroquinoline-3-carbaldehyde; 4-tert-butylmagnesium bromide; In tetrahydrofuran; at -50 - -20 ℃; for 1h; Inert atmosphere;

With methanol; In tetrahydrofuran; at -50 ℃;

Reference yield:

: 1332486-39-1
(S)-ethyl 5-hydroxy-4-iodo-2-isopropyl-7,7-dimethyl-5,6,7,8-tetrahydroquinoline-3-carboxylate

: 1332486-60-8
(S)-3-((R)-(4-tert-butylphenyl)(hydroxy)methyl)-4-iodo-2-isopropyl-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-5-ol

: 1332491-49-2
(S)-3-((S)-(4-tert-butylphenyl)(hydroxy)methyl)-4-iodo-2-isopropyl-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-5-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: 2,6-dimethylpyridine / tetrahydrofuran / 12 h / 0 - 20 °C

2.1: diisobutylaluminium hydride / dichloromethane / 2 h / 0 °C

2.2: 0.08 h

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

4.1: sodium hydrogencarbonate; iodine / 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / toluene; water / 20 h / 20 °C / Inert atmosphere

5.1: tetrahydrofuran / 1 h / -50 - -20 °C / Inert atmosphere

5.2: -50 °C

With 2,6-dimethylpyridine; tetrabutyl ammonium fluoride; iodine; diisobutylaluminium hydride; sodium hydrogencarbonate; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; In tetrahydrofuran; dichloromethane; water; toluene;

Reference yield:

: 873-95-0
1-amino-5,5-dimethylcyclohexen-3-one

: 1332486-60-8
(S)-3-((R)-(4-tert-butylphenyl)(hydroxy)methyl)-4-iodo-2-isopropyl-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-5-ol

: 1332491-49-2
(S)-3-((S)-(4-tert-butylphenyl)(hydroxy)methyl)-4-iodo-2-isopropyl-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-5-ol

Guidance literature:: Multi-step reaction with 9 steps

1.1: 0.17 h / 210 °C

2.1: acetyl chloride; sodium iodide / acetonitrile / 3 h / 50 °C

3.1: (1R,2S)-1-Amino-2-indanol; borane N,N-diethylaniline complex / tetrahydrofuran / 28 h / 0 - 20 °C

3.2: 0.17 h

4.1: 2,6-dimethylpyridine / tetrahydrofuran / 12 h / 0 - 20 °C

5.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / toluene; tetrahydrofuran / 12 h / 85 °C / Inert atmosphere; Reflux

6.1: diisobutylaluminium hydride / dichloromethane / 2 h / 0 °C

6.2: 0.08 h

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

8.1: sodium hydrogencarbonate; iodine / 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / toluene; water / 20 h / 20 °C / Inert atmosphere

9.1: tetrahydrofuran / 1 h / -50 - -20 °C / Inert atmosphere

9.2: -50 °C

With 2,6-dimethylpyridine; borane N,N-diethylaniline complex; (1R,2S)-1-Amino-2-indanol; tetrabutyl ammonium fluoride; iodine; diisobutylaluminium hydride; sodium hydrogencarbonate; acetyl chloride; sodium iodide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; In tetrahydrofuran; dichloromethane; water; toluene; acetonitrile;