N-{1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(3-oxa-1-thia-2-phospha-spiro[4.5]dec-2-yloxy)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide

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Chemical Name:N-{1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(3-oxa-1-thia-2-phospha-spiro[4.5]dec-2-yloxy)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide
CAS No.:212574-99-7
Molecular Formula:C₄₄H₄₆N₃O₈PS
Molecular Weight:807.904
Hs Code.:

N-{1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(3-oxa-1-thia-2-phospha-spiro[4.5]dec-2-yloxy)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide

Synonyms:N-{1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(3-oxa-1-thia-2-phospha-spiro[4.5]dec-2-yloxy)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide

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Chemical Property of N-{1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(3-oxa-1-thia-2-phospha-spiro[4.5]dec-2-yloxy)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide

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Technology Process of N-{1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(3-oxa-1-thia-2-phospha-spiro[4.5]dec-2-yloxy)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide

There total 5 articles about N-{1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(3-oxa-1-thia-2-phospha-spiro[4.5]dec-2-yloxy)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67219-55-0
4-N-Benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine

: 198637-74-0
2-chloro-“spiro”-4,4-pentamethylene-1,3,2-oxathiaphospholane

: 212574-99-7
N-{1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(3-oxa-1-thia-2-phospha-spiro[4.5]dec-2-yloxy)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; for 0.0833333h; Ambient temperature;
DOI:10.1021/ja973801j

Reference yield:

: 212574-88-4
1-mercapto-1,1-pentamethylenethan-2-ol

: 212574-99-7
N-{1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(3-oxa-1-thia-2-phospha-spiro[4.5]dec-2-yloxy)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: 76 percent / PCl₃, pyridine / benzene

2: iPr₂NEt / acetonitrile / 0.08 h / Ambient temperature

With pyridine; N-ethyl-N,N-diisopropylamine; phosphorus trichloride; In acetonitrile; benzene;
DOI:10.1080/07328319808004710

Reference yield:

: 52958-74-4
1-[(2-formylcyclohexyl)disulfanyl]cyclohexanecarbaldehyde

: 212574-99-7
N-{1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(3-oxa-1-thia-2-phospha-spiro[4.5]dec-2-yloxy)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / NaBH₄ / propan-2-ol

2: 70 percent / LiAlH₄ / diethyl ether

3: 76 percent / PCl₃, pyridine / benzene

4: iPr₂NEt / acetonitrile / 0.08 h / Ambient temperature

With pyridine; sodium tetrahydroborate; lithium aluminium tetrahydride; N-ethyl-N,N-diisopropylamine; phosphorus trichloride; In diethyl ether; isopropyl alcohol; acetonitrile; benzene;
DOI:10.1080/07328319808004710