1-(2-(difluoromethyl)pyrimidin-5-yl)-4,4-difluorocyclohexanecarbonitrile

Base Information

Chemical Name:1-(2-(difluoromethyl)pyrimidin-5-yl)-4,4-difluorocyclohexanecarbonitrile
CAS No.:1600498-64-3
Molecular Formula:C₁₂H₁₁F₄N₃
Molecular Weight:273.233
Hs Code.:

Synonyms:1-(2-(difluoromethyl)pyrimidin-5-yl)-4,4-difluorocyclohexanecarbonitrile

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Chemical Property of 1-(2-(difluoromethyl)pyrimidin-5-yl)-4,4-difluorocyclohexanecarbonitrile

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Technology Process of 1-(2-(difluoromethyl)pyrimidin-5-yl)-4,4-difluorocyclohexanecarbonitrile

There total 4 articles about 1-(2-(difluoromethyl)pyrimidin-5-yl)-4,4-difluorocyclohexanecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.4%

: 98-08-8
α,α,α-trifluorotoluene

: 1600498-56-3
4,4-difluoro-1-(6-fluoro-pyridin-3-yl)-cyclohexanecarbonitrile

: 1600498-64-3
1-(2-(difluoromethyl)pyrimidin-5-yl)-4,4-difluorocyclohexanecarbonitrile

Guidance literature:: With tert.-butylhydroperoxide; bis(((difluoromethyl)sulfinyl)oxy)zinc; trifluoroacetic acid; In water; at 20 ℃;

Reference yield:

: 1600498-50-7
1-(6-fluoro-pyridin-3-yl)-4-oxo-cyclohexanecarbonitrile

: 1600498-64-3
1-(2-(difluoromethyl)pyrimidin-5-yl)-4,4-difluorocyclohexanecarbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: ethanaminium,N-(difluoro-λ⁴-sulfanylidene)-N-ethyl-,tetrafluoroborate / dichloromethane / 20 °C / Inert atmosphere

2: trifluoroacetic acid; tert.-butylhydroperoxide; bis(((difluoromethyl)sulfinyl)oxy)zinc / water / 20 °C

With tert.-butylhydroperoxide; bis(((difluoromethyl)sulfinyl)oxy)zinc; ethanaminium,N-(difluoro-λ⁴-sulfanylidene)-N-ethyl-,tetrafluoroborate; trifluoroacetic acid; In dichloromethane; water;

Reference yield:

: 337965-61-4
(6-fluoro-pyridin-3-yl)-acetonitrile

: 1600498-64-3
1-(2-(difluoromethyl)pyrimidin-5-yl)-4,4-difluorocyclohexanecarbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: potassium tert-butylate / tetrahydrofuran; ethanol / 4 h / -70 °C

2: sodium chloride / water; dimethyl sulfoxide / 3 h / 160 °C

3: ethanaminium,N-(difluoro-λ⁴-sulfanylidene)-N-ethyl-,tetrafluoroborate / dichloromethane / 20 °C / Inert atmosphere

4: trifluoroacetic acid; tert.-butylhydroperoxide; bis(((difluoromethyl)sulfinyl)oxy)zinc / water / 20 °C

With tert.-butylhydroperoxide; bis(((difluoromethyl)sulfinyl)oxy)zinc; potassium tert-butylate; ethanaminium,N-(difluoro-λ⁴-sulfanylidene)-N-ethyl-,tetrafluoroborate; trifluoroacetic acid; sodium chloride; In tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide;