(4S,5R)-1-(4-bromophenyl)-4,5-dihydro-3,4-diphenyl-5-(oxazolidin-2-one-3-carbonyl)-1H-pyrazole

Base Information

Chemical Name:(4S,5R)-1-(4-bromophenyl)-4,5-dihydro-3,4-diphenyl-5-(oxazolidin-2-one-3-carbonyl)-1H-pyrazole
CAS No.:858342-81-1
Molecular Formula:C₂₅H₂₀BrN₃O₃
Molecular Weight:490.356
Hs Code.:

Synonyms:(4S,5R)-1-(4-bromophenyl)-4,5-dihydro-3,4-diphenyl-5-(oxazolidin-2-one-3-carbonyl)-1H-pyrazole

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Chemical Property of (4S,5R)-1-(4-bromophenyl)-4,5-dihydro-3,4-diphenyl-5-(oxazolidin-2-one-3-carbonyl)-1H-pyrazole

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Technology Process of (4S,5R)-1-(4-bromophenyl)-4,5-dihydro-3,4-diphenyl-5-(oxazolidin-2-one-3-carbonyl)-1H-pyrazole

There total 4 articles about (4S,5R)-1-(4-bromophenyl)-4,5-dihydro-3,4-diphenyl-5-(oxazolidin-2-one-3-carbonyl)-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 918497-04-8
(Z)-N-4-bromophenylbenzohydrazonoyl bromide

: 109299-93-6
3-((E)-3-phenyl-2-propenoyl)-1,3-oxazolidin-2-one

: 858342-81-1
(4S,5R)-1-(4-bromophenyl)-4,5-dihydro-3,4-diphenyl-5-(oxazolidin-2-one-3-carbonyl)-1H-pyrazole

Guidance literature:: With 4 A molecular sieve; magnesium bis(trifluoromethane solfonyl)imide; N-ethyl-N,N-diisopropylamine; In dichloromethane; at -78 ℃; for 6h;
DOI:10.1021/ja051650b

Reference yield:

: N-(4-bromo-phenyl)-N'-[1-phenyl-meth-(E)-ylidene]-hydrazine

: 858342-81-1
(4S,5R)-1-(4-bromophenyl)-4,5-dihydro-3,4-diphenyl-5-(oxazolidin-2-one-3-carbonyl)-1H-pyrazole

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / NBS; Me₂S / CH₂Cl₂ / 4 h / -78 - 20 °C

2: Mg(NTf₂)2; chiral ligand; 4 A molecular sieves / iPr₂NEt / CH₂Cl₂ / 6 h / -78 °C

With N-Bromosuccinimide; dimethylsulfide; 4 A molecular sieve; magnesium bis(trifluoromethane solfonyl)imide; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1021/ja051650b

Reference yield:

: 140-10-3
(E)-3-phenylacrylic acid

: 858342-81-1
(4S,5R)-1-(4-bromophenyl)-4,5-dihydro-3,4-diphenyl-5-(oxazolidin-2-one-3-carbonyl)-1H-pyrazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: (COCl)2; DMF / CH₂Cl₂ / 2 h / 20 °C

2.1: NaH / tetrahydrofuran / 0.92 h / 0 - 20 °C

2.2: tetrahydrofuran / 4 h / 20 °C

3.1: Mg(NTf₂)2; chiral ligand; 4 A molecular sieves / iPr₂NEt / CH₂Cl₂ / 6 h / -78 °C

With oxalyl dichloride; 4 A molecular sieve; sodium hydride; N,N-dimethyl-formamide; magnesium bis(trifluoromethane solfonyl)imide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja051650b