N-(dodecyloxycarbonyl)-(L-phenylalanyl)-L-histidyl-L-leucine methyl ester

Base Information

• Chemical Name: N-(dodecyloxycarbonyl)-(L-phenylalanyl)-L-histidyl-L-leucine methyl ester
• CAS No.: 146027-99-8
• Molecular Formula: C₃₅H₅₅N₅O₆
• Molecular Weight: 641.852

Synonyms:N-(dodecyloxycarbonyl)-(L-phenylalanyl)-L-histidyl-L-leucine methyl ester

Chemical Property of N-(dodecyloxycarbonyl)-(L-phenylalanyl)-L-histidyl-L-leucine methyl ester

Chemical Property:

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Technology Process of N-(dodecyloxycarbonyl)-(L-phenylalanyl)-L-histidyl-L-leucine methyl ester

There total 1 articles about N-(dodecyloxycarbonyl)-(L-phenylalanyl)-L-histidyl-L-leucine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

methyl (L)-leucinate hydrochloride (7517-19-3) + N-(dodecyloxycarbonyl)-(L-phenylalanyl)-L-histidine → N-(dodecyloxycarbonyl)-(L-phenylalanyl)-L-histidyl-L-leucine methyl ester (146027-99-8)

Guidance literature:

With dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide;

DOI:10.1002/recl.19921111101

Reference yield: 75.0%

N-(dodecyloxycarbonyl)-(L-phenylalanyl)-L-histidyl-L-leucine methyl ester (146027-99-8) → N-(dodecyloxycarbonyl)-(L-phenylalanyl)-L-histidyl-L-leucine (146027-74-9)

Guidance literature:

With sodium hydroxide; In ethanol;

DOI:10.1002/recl.19931120102

Reference yield:

N-(dodecyloxycarbonyl)-(L-phenylalanyl)-L-histidyl-L-leucine methyl ester (146027-99-8) → N-(dodecyloxycarbonyl)-(L-phenylalanyl)-L-histidyl-L-leucyl-L-leucine (146027-87-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 70 percent / NaOH / aq. ethanol

2: 60 percent / 1,3-dicyclohexylcarbodiimide / dimethylformamide

3: 75 percent / NaOH / aq. ethanol

With sodium hydroxide; dicyclohexyl-carbodiimide; In ethanol; N,N-dimethyl-formamide;

DOI:10.1002/recl.19921111101

upstream raw materials:

methyl (L)-leucinate hydrochloride

Downstream raw materials:

N-(dodecyloxycarbonyl)-(L-phenylalanyl)-L-histidyl-L-leucine

N-(dodecyloxycarbonyl)-(L-phenylalanyl)-L-histidyl-L-leucyl-L-alanine methyl ester

N-(dodecyloxycarbonyl)-(L-phenylalanyl)-L-histidyl-L-leucyl-L-leucyl-L-leucine methyl ester

N-(dodecyloxycarbonyl)-(L-phenylalanyl)-L-histidyl-L-leucyl-L-leucine

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