13-(2-bromobenzyl)berberine bromide

Base Information

• Chemical Name: 13-(2-bromobenzyl)berberine bromide
• CAS No.: 1390654-18-8
• Molecular Formula: Br*C₂₇H₂₃BrNO₄
• Molecular Weight: 585.292
• Mol file: 1390654-18-8.mol

Synonyms:13-(2-bromobenzyl)berberine bromide

Chemical Property of 13-(2-bromobenzyl)berberine bromide

Chemical Property:

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Technology Process of 13-(2-bromobenzyl)berberine bromide

There total 1 articles about 13-(2-bromobenzyl)berberine bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

7,8-dihydroberberine (483-15-8) + 1-Bromo-2-bromomethyl-benzene (3433-80-5) → 13-(2-bromobenzyl)berberine bromide (1390654-18-8)

Guidance literature:

With potassium iodide; In acetonitrile; for 4h; Reflux;

DOI:10.1002/cmdc.201300332

upstream raw materials:

7,8-dihydroberberine

1-Bromo-2-bromomethyl-benzene

Refernces

• 1、 Liu, Hong,Wang, Liang,Li, Yan,Liu, Jiang,An, Maomao,Zhu, Shaolong,Cao, Yongbing,Jiang, Zhihui,Zhao, Mingzhu,Cai, Zhan,Dai, Li,Ni, Tingjunhong,Liu, Wei,Chen, Simin,Wei, Changqing,Zang, Chengxu,Tian, Shujuan,Yang, Jingyu,Wu, Chunfu,Zhang, Dazhi,Liu, Hua,Jiang, Yuanying. "Structural optimization of berberine as a synergist to restore antifungal activity of fluconazole against drug-resistant Candida albicans". supporting information. p. 207 - 216. Retrieved 2014/01/17.