(S)-4-(2-(((benzyloxy)carbonyl)amino)-3-methoxy-3-oxopropyl)phenyl pyrrolidine-1-carboxylate

Base Information

Chemical Name:(S)-4-(2-(((benzyloxy)carbonyl)amino)-3-methoxy-3-oxopropyl)phenyl pyrrolidine-1-carboxylate
CAS No.:1541175-25-0
Molecular Formula:C₂₃H₂₆N₂O₆
Molecular Weight:426.469
Hs Code.:

Synonyms:(S)-4-(2-(((benzyloxy)carbonyl)amino)-3-methoxy-3-oxopropyl)phenyl pyrrolidine-1-carboxylate

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Chemical Property of (S)-4-(2-(((benzyloxy)carbonyl)amino)-3-methoxy-3-oxopropyl)phenyl pyrrolidine-1-carboxylate

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Technology Process of (S)-4-(2-(((benzyloxy)carbonyl)amino)-3-methoxy-3-oxopropyl)phenyl pyrrolidine-1-carboxylate

There total 1 articles about (S)-4-(2-(((benzyloxy)carbonyl)amino)-3-methoxy-3-oxopropyl)phenyl pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1192-63-8
1-pyrrolidinecarbonyl chloride

: 13512-31-7
N-(benzyloxycarbonyl)-L-tyrosine methyl ester

: 1541175-25-0
(S)-4-(2-(((benzyloxy)carbonyl)amino)-3-methoxy-3-oxopropyl)phenyl pyrrolidine-1-carboxylate

Guidance literature:: With potassium carbonate; In acetonitrile; at 100 ℃; for 0.75h; Microwave irradiation;
DOI:10.1039/c3ob42332h

Reference yield:

: 1541175-25-0
(S)-4-(2-(((benzyloxy)carbonyl)amino)-3-methoxy-3-oxopropyl)phenyl pyrrolidine-1-carboxylate

: 1541175-33-0
4-((2S)-2-((2S,4R)-4-azido-1-(phenylsulfonyl)pyrrolidine-2-carboxamido)-3-methoxy-3-oxopropyl)phenyl pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: palladium 10% on activated carbon; hydrogen / methanol / 2 h

2.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 0.17 h / 0 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In methanol; N,N-dimethyl-formamide;
DOI:10.1039/c3ob42332h

Reference yield:

: 1541175-25-0
(S)-4-(2-(((benzyloxy)carbonyl)amino)-3-methoxy-3-oxopropyl)phenyl pyrrolidine-1-carboxylate

: 1541175-34-1
4-((2S)-3-methoxy-3-oxo-2-((2S,4R)-4-(4-((3-oxo-1-phenyl-2,8,11,14-tetraoxa-4-azaheptadecan-17-yl)carbamoyl)-1H-1,2,3-triazol-1-yl)-1-(phenylsulfonyl)pyrrolidine-2-carboxamido)propyl)phenyl pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: palladium 10% on activated carbon; hydrogen / methanol / 2 h

2.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 0.17 h / 0 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

3.1: sodium L-ascorbate; copper(II) sulfate; tris[(1-benzyl-1H-1,2,3-triazol-4yl)methyl]amine / water; tetrahydrofuran; N,N-dimethyl-formamide / 2 h / 60 °C

With palladium 10% on activated carbon; hydrogen; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; copper(II) sulfate; sodium L-ascorbate; N-ethyl-N,N-diisopropylamine; tris[(1-benzyl-1H-1,2,3-triazol-4yl)methyl]amine; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
DOI:10.1039/c3ob42332h