5'-O-(monomethoxytrityl)-N⁴,2'-O-3'-O-tris<2-(4-nitrophenyl)ethoxycarbonyl>cytidine

Base Information

• Chemical Name: 5'-O-(monomethoxytrityl)-N⁴,2'-O-3'-O-tris<2-(4-nitrophenyl)ethoxycarbonyl>cytidine
• CAS No.: 112123-75-8
• Molecular Formula: C₅₆H₅₀N₆O₁₈
• Molecular Weight: 1095.04

Synonyms:5'-O-(monomethoxytrityl)-N⁴,2'-O-3'-O-tris<2-(4-nitrophenyl)ethoxycarbonyl>cytidine

Chemical Property of 5'-O-(monomethoxytrityl)-N⁴,2'-O-3'-O-tris<2-(4-nitrophenyl)ethoxycarbonyl>cytidine

Chemical Property:

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Technology Process of 5'-O-(monomethoxytrityl)-N⁴,2'-O-3'-O-tris<2-(4-nitrophenyl)ethoxycarbonyl>cytidine

There total 5 articles about 5'-O-(monomethoxytrityl)-N⁴,2'-O-3'-O-tris<2-(4-nitrophenyl)ethoxycarbonyl>cytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

1-methyl-3-[2-(4-nitrophenyl)ethoxycarbonyl]imidazolium chloride (88091-70-7) + 5'-O-(monomethoxytrityl)-N4-<2-(4-nitrophenyl)ethoxycarbonyl>cytidine (148144-72-3) → 5'-O-(monomethoxytrityl)-N4,2'-O-3'-O-tris<2-(4-nitrophenyl)ethoxycarbonyl>cytidine (112123-75-8)

Guidance literature:

With dmap; In dichloromethane; for 2h; Ambient temperature;

DOI:10.1002/hlca.19930760122

Reference yield:

1-methyl-3-[2-(4-nitrophenyl)ethoxycarbonyl]imidazolium chloride (88091-70-7) → 5'-O-(monomethoxytrityl)-N4,2'-O-3'-O-tris<2-(4-nitrophenyl)ethoxycarbonyl>cytidine (112123-75-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 1) hexamethyldisilazane, (NH₄)2SO₄ / 1) dioxane, 3.5 h, reflux, 2) CH₂Cl₂, RT, 1 h

2: 87 percent / pyridine / 48 h / Ambient temperature

3: 89 percent / 4-dimethylaminopyridine / CH₂Cl₂ / 2 h / Ambient temperature

With pyridine; dmap; ammonium sulfate; 1,1,1,3,3,3-hexamethyl-disilazane; In dichloromethane;

DOI:10.1002/hlca.19930760122

Reference yield:

N4-<2-(4-nitrophenyl)ethoxycarbonyl>cytidine (88121-72-6) → 5'-O-(monomethoxytrityl)-N4,2'-O-3'-O-tris<2-(4-nitrophenyl)ethoxycarbonyl>cytidine (112123-75-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / pyridine / 48 h / Ambient temperature

2: 89 percent / 4-dimethylaminopyridine / CH₂Cl₂ / 2 h / Ambient temperature

With pyridine; dmap; In dichloromethane;

DOI:10.1002/hlca.19930760122

upstream raw materials:

1-methyl-3-[2-(4-nitrophenyl)ethoxycarbonyl]imidazolium chloride

5'-O-(monomethoxytrityl)-N⁴-<2-(4-nitrophenyl)ethoxycarbonyl>cytidine

N⁴-<2-(4-nitrophenyl)ethoxycarbonyl>cytidine

mono-4-methoxytrityl chloride

Downstream raw materials:

O^5'-(4-methoxy-trityl)-cytidine

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